Actively Recruiting
The Voided Urinary, Perineal, and Faecal Microbiota Among Children and Adolescents - the PpUF-study.
Led by Aalborg University Hospital · Updated on 2026-04-17
110
Participants Needed
4
Research Sites
285 weeks
Total Duration
On this page
Sponsors
A
Aalborg University Hospital
Lead Sponsor
A
Aarhus University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to investigate whether the voided urinary, perineal/preputial, and the fecal microbiota are different between children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy children without bladder symptoms. Moreover, the study aims to investigate if the microbiota is different according to the severity of DUI and if the microbiota is changed throughout treatment of DUI. A follow-up study will as well be performed on healthy children to investigate how the microbiota evolves with increasing age and pubertal stage. Children with OAB and DUI will be recruited from involved pediatric departments, and specimen in the form of urine, perineal/preputial swabs, and feces will be collected according to the protocol.
CONDITIONS
Official Title
The Voided Urinary, Perineal, and Faecal Microbiota Among Children and Adolescents - the PpUF-study.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children with overactive bladder diagnosed according to International Children's Continence Society criteria (cases only)
- Children with at least two wet days per week (cases only)
- Children with no prior pharmacological treatment of overactive bladder and daytime urinary incontinence (cases only)
- Healthy children with no lower urinary tract symptoms (healthy participants only)
- Negative urine dipstick test
You will not qualify if you...
- Known urogenital abnormalities affecting lower urinary tract function
- Known gastrointestinal or neurological diseases
- Use of systemic drugs within five half-lives of the drug
- Use of systemic antibiotics within three months before inclusion
- Current urinary tract infection
- Urinary tract infection within the last three months prior to inclusion
- Current constipation
- Abnormal uroflowmetry (healthy participants only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Department of Pediatrics, Aalborg University Hospital
Aalborg, Denmark, 9000
Actively Recruiting
2
Department of Pediatrics, Aarhus University Hospital
Aarhus, Denmark, 8200
Not Yet Recruiting
3
Department of Pediatrics, Regional Hospital West Jutland
Herning, Denmark, 7400
Actively Recruiting
4
Department of Pediatrics, North Denmark Regional Hospital
Hjørring, Denmark, 9800
Not Yet Recruiting
Research Team
K
Kristina Thorsteinsson, MD
CONTACT
S
Søren Hagstrøm, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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