Actively Recruiting
Volrustomig Priming Regimens Exploratory Phase II Platform Study
Led by AstraZeneca · Updated on 2026-05-12
180
Participants Needed
77
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Purpose of this study is to assess the safety, tolerability, pharmacokinetics, immunogenicity, and antitumor activity of volrustomig in combination with other anticancer drugs in participants with specified solid tumors.
CONDITIONS
Official Title
Volrustomig Priming Regimens Exploratory Phase II Platform Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 with no deterioration
- Life expectancy of at least 12 weeks
- Adequate organ and bone marrow function
- Body weight greater than 35 kilograms at screening and randomization
- Histologically or cytologically confirmed non-squamous NSCLC in substudy 1 or squamous/non-squamous metastatic NSCLC in substudy 2
- No sensitizing epidermal growth factor receptor (EGFR) mutations
- No tumor genomic alterations with approved targeted first-line therapies based on local testing
- At least one measurable lesion not previously irradiated, at least 10 millimeters in longest diameter at baseline
You will not qualify if you...
- Spinal cord compression
- History of primary active immunodeficiency
- Active or prior autoimmune or inflammatory disorders
- Mixed small-cell lung cancer and NSCLC histology or sarcomatoid variant
- Brain metastases unless asymptomatic, stable, and off steroids for at least 14 days before study
- Less than 2 weeks since end of radiation therapy
- Prior chemotherapy or systemic therapy for Stage IV NSCLC (prior platinum-containing adjuvant, neoadjuvant, or definitive chemoradiation for local disease allowed if progression occurred more than 12 months after last therapy)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 77 locations
1
Research Site
Los Angeles, California, United States, 90067
Actively Recruiting
2
Research Site
Grand Junction, Colorado, United States, 81501
Actively Recruiting
3
Research Site
Wheat Ridge, Colorado, United States, 80033
Actively Recruiting
4
Research Site
Baltimore, Maryland, United States, 21231
Withdrawn
5
Research Site
Detroit, Michigan, United States, 48202
Withdrawn
6
Research Site
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
7
Research Site
Tacoma, Washington, United States, 98405
Withdrawn
8
Research Site
Montreal, Quebec, Canada, H4A 3J1
Withdrawn
9
Research Site
Beijing, China, 100730
Actively Recruiting
10
Research Site
Hangzhou, China, 310014
Actively Recruiting
11
Research Site
Jinan, China, 250013
Actively Recruiting
12
Research Site
Yantai, China, 264000
Actively Recruiting
13
Research Site
Zhengzhou, China, 450000
Actively Recruiting
14
Research Site
Bois-Guillaume, France, 76031
Actively Recruiting
15
Research Site
Caen, France, 14076
Actively Recruiting
16
Research Site
Créteil, France, 94000
Withdrawn
17
Research Site
Dijon, France, 21079
Actively Recruiting
18
Research Site
Montpellier, France, 34070
Actively Recruiting
19
Research Site
Batumi, Georgia, 6010
Actively Recruiting
20
Research Site
Tbilisi, Georgia, '0159
Actively Recruiting
21
Research Site
Tbilisi, Georgia, 0112
Actively Recruiting
22
Research Site
Tbilisi, Georgia, 0114
Actively Recruiting
23
Research Site
Tbilisi, Georgia, 0144
Actively Recruiting
24
Research Site
Tbilisi, Georgia, 186
Actively Recruiting
25
Research Site
Athens, Greece, 115 27
Not Yet Recruiting
26
Research Site
Athens, Greece, 12462
Actively Recruiting
27
Research Site
Elaiones, Greece, 546 23
Actively Recruiting
28
Research Site
Piraeus, Greece, 185 47
Actively Recruiting
29
Research Site
Thessaloniki, Greece, 57001
Actively Recruiting
30
Research Site
Genoa, Italy, 16132
Actively Recruiting
31
Research Site
Meldola, Italy, 47014
Actively Recruiting
32
Research Site
Milan, Italy, 20133
Actively Recruiting
33
Research Site
Naples, Italy, 80131
Actively Recruiting
34
Research Site
Orbassano, Italy, 10043
Actively Recruiting
35
Research Site
Perugia, Italy, 06132
Actively Recruiting
36
Research Site
Rozzano, Italy, 20089
Actively Recruiting
37
Research Site
Udine, Italy, 33100
Actively Recruiting
38
Research Site
Verona, Italy, 37134
Actively Recruiting
39
Research Site
Kuala Lumpur, Malaysia, 59100
Actively Recruiting
40
Research Site
Kuching, Malaysia, 93586
Actively Recruiting
41
Research Site
Perai, Malaysia, 13700
Actively Recruiting
42
Research Site
Lisbon, Portugal, 1169-050
Actively Recruiting
43
Research Site
Lisbon, Portugal, 1400-038
Actively Recruiting
44
Research Site
Lisbon, Portugal, 1500-458
Withdrawn
45
Research Site
Lisbon, Portugal, 1649-035
Actively Recruiting
46
Research Site
Porto, Portugal, 4099-001
Actively Recruiting
47
Research Site
Porto, Portugal, 4100-180
Withdrawn
48
Research Site
Cluj-Napoca, Romania, 400641
Actively Recruiting
49
Research Site
Craiova, Romania, 200542
Actively Recruiting
50
Research Site
Floreşti, Romania, 407280
Actively Recruiting
51
Research Site
Belgrade, Serbia, 11000
Withdrawn
52
Research Site
Belgrade, Serbia, 11000
Actively Recruiting
53
Research Site
Kamenitz, Serbia, 21204
Actively Recruiting
54
Research Site
Kragujevac, Serbia, 34000
Actively Recruiting
55
Research Site
Seongnam, South Korea, 13620
Completed
56
Research Site
Seoul, South Korea, 03722
Actively Recruiting
57
Research Site
Seoul, South Korea, 06591
Withdrawn
58
Research Site
Suwon, South Korea, 16247
Actively Recruiting
59
Research Site
A Coruña, Spain, 15009
Actively Recruiting
60
Research Site
Alcorcón, Spain, 28922
Actively Recruiting
61
Research Site
Barcelona, Spain, 08041
Actively Recruiting
62
Research Site
Madrid, Spain, 28041
Actively Recruiting
63
Research Site
Málaga, Spain, 29004
Actively Recruiting
64
Research Site
Pamplona, Spain, 31008
Actively Recruiting
65
Research Site
Santander, Spain, 39008
Actively Recruiting
66
Research Site
Santiago de Compostela, Spain, 15706
Actively Recruiting
67
Research Site
Valencia, Spain, 46015
Actively Recruiting
68
Research Site
Valencia, Spain, 46026
Actively Recruiting
69
Research Site
Basel, Switzerland, 4031
Withdrawn
70
Research Site
Geneva, Switzerland, 1205
Actively Recruiting
71
Research Site
Lausanne, Switzerland, 1011
Actively Recruiting
72
Research Site
Winterthur, Switzerland, 8401
Actively Recruiting
73
Research Site
Zurich, Switzerland, 8091
Actively Recruiting
74
Research Site
Changhua, Taiwan, 50006
Actively Recruiting
75
Research Site
New Taipei City, Taiwan, 23561
Actively Recruiting
76
Research Site
Taipei, Taiwan, 106
Actively Recruiting
77
Research Site
Taipei, Taiwan, 110
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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