Tolerance to Fluid Removal During Continuous Renal Replacement Therapy in Critically Ill Adults with Acute Kidney Injury

What this Trial Is About

Researchers are studying adults with acute kidney injury AKI who are critically ill and receiving continuous renal replacement therapy CRRT. The study aims to understand how well patients tolerate fluid removal through net ultrafiltration UFNET during CRRT. This is an observational study focusing on how changes in heart function, blood flow, tissue perfusion, and congestion-related signs might predict intolerance to fluid removal before severe low blood pressure occurs. Participants are critically ill adults receiving CRRT with UFNET prescribed by their clinical care team. The study does not change or assign treatments but monitors patients using multiple methods. These include clinical assessments, hemodynamic monitoring, cardiac ultrasound, venous congestion evaluation, peripheral perfusion measurements, biochemical tests, and fluid balance tracking. Data is collected before and during the early phase of fluid removal, with additional recordings if signs of intolerance appear. Participants will be assessed at scheduled times using standard medical records, bedside monitors, laboratory results, and ultrasound exams. The study will track the development of ultrafiltration intolerance within 24 hours of UFNET start. Researchers will analyze various physiological and clinical factors to identify predictors of intolerance. The study may help tailor fluid removal strategies and improve CRRT safety in critically ill patients with AKI. Participation includes monitoring without altering usual care, and data will be kept confidential and anonymized.

Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients