Actively Recruiting
V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)
Led by University Hospital, Angers · Updated on 2025-12-08
50
Participants Needed
1
Research Sites
133 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aim to compare the effect of Positive End Expiratory Pressure (PEEP) on ventilation/perfusion mismatch in two phenotypes of patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), characterized by their respiratory system elastance (Ers). Ventilation/perfusion mismatch will be assessed by Electrical Impedance Tomography (EIT).
CONDITIONS
Official Title
V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Intubated patients with moderate to severe ARDS (PaO2/FiO2 60 200 mmHg at PEEP 5 cmH2O)
- Undergoing deep sedation
- On controlled mechanical ventilation
- Between 24 hours and 5 days after intubation
You will not qualify if you...
- Age under 18 years or pregnancy
- Patients under legal protection
- Contraindications to Electrical Impedance Tomography (e.g., severe chest trauma or wounds)
- Pneumothorax or patients undergoing ECMO
- Body mass index (BMI) 35 kg/m2 or higher
- Hemodynamic instability with mean arterial pressure under 60 mmHg despite vasopressors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Angers Hospital
Angers, Maine et Loire, France, 49933
Actively Recruiting
Research Team
F
François Beloncle, MD
CONTACT
U
UH Angers DRCI
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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