Actively Recruiting
Water-based Activity to Enhance Recovery in Long COVID-19
Led by VA Office of Research and Development · Updated on 2025-01-28
50
Participants Needed
1
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This two-year study will evaluate the feasibility and safety of an exercise + cognitive training program to improve neurological symptoms of long-COVID. This is a two-phased trial: 1) an exercise phase and 2) a cognitive training phase. The exercise phase will be an aquatic based exercise program. A combination exercise + memory training programs designed for persons with cognitive impairment have significantly improved memory more than other single intervention groups (exercise only, cognitive training only) and given the success of combination training programs with healthy adults, it is important to adapt these programs for persons with neurological symptoms of long-COVID.
CONDITIONS
Official Title
Water-based Activity to Enhance Recovery in Long COVID-19
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans aged 18 to 89 years
- Previous COVID-19 infection documented at least 6 months ago
- Persistent neurological symptoms (e.g., brain fog, cognitive impairment) starting within 3 months of COVID-19 onset and lasting at least 8 weeks
- Adequate vision and hearing to complete neuropsychological tests
- Willingness to participate in an 8-month clinical trial
- Primary Care Provider approval to engage in water-based physical exercise
You will not qualify if you...
- Current uncontrolled severe psychotic disorder as determined by Mini International Neuropsychiatric Interview (MINI)
- History of neurological, neurodegenerative, or systemic illnesses affecting central nervous system function before COVID-19 diagnosis (e.g., multiple sclerosis, seizures, stroke, Parkinson's disease, Alzheimer's disease, liver failure, kidney failure, congestive heart failure, systemic cancer)
- Severe cardiac disease including uncontrolled atrial fibrillation, severe ventricular arrhythmias, active pericarditis or myocarditis, Class III/IV heart failure, or ejection fraction below 20%
- Thrombophlebitis or pulmonary disease causing oxygen saturation drop below 90% with exercise without oxygen
- Embolism within the past 6 months
- Inability to participate in an exercise stress test
- Inability to read, understand, and voluntarily sign informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States, 94304-1207
Actively Recruiting
Research Team
J
Jennifer K Fairchild, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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