Actively Recruiting
Weaning From Mechanical Ventilation in Patients With Acute Brain Injury
Led by Southeast University, China · Updated on 2025-11-18
406
Participants Needed
2
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute brain injury (ABI) patients frequently necessate intubation and invasive mechanical ventilation (IMV). While some ABI patients are capable of breathing spontaneously, which is one of the main criteria of extubation and weaning. However, the rate of extubation failure was significantly higher in ABI patients compared with non-neurological critical care patients. In patients who have failed one or several trials of extubation, tracheostomy is recommend according to the latest ESICM consensus. Tracheostomy can enhance comfort, improve pulmonary hygiene and decrease sedation requirement, which could facilitate the liberation from ventilator. Numerous studies have explored the causes of weaning failure and provide various predictive models in guiding extubation and tracheostomy. Yet, due to limitations of such as small sample size or a lack of external validation, there is paucity of practical weaning algorithm tailored for ABI patients. The liberation from IMV in ABI patients still remains challenging with poor level of evidence in current guidelines or expert consensus. We aim to describe the weaning outcomes in ABI patients, and further investigate the potential predictors of weaning success in ABI patients.
CONDITIONS
Official Title
Weaning From Mechanical Ventilation in Patients With Acute Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute brain injury
- Age 18 years or older
- Invasive mechanical ventilation for at least 24 hours
You will not qualify if you...
- Tracheostomy before ICU admission
- Pregnant or lactating
- Cervical spinal cord injury
- Decision to receive palliative care within 24 hours of ICU admission
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Ling Liu
Nanjing, Jiangsu, China, 210009
Actively Recruiting
2
Department of Critical Care Medicine, Zhongda Hospital
Nanjing, China
Actively Recruiting
Research Team
L
Ling Liu, PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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