Actively Recruiting
Prediction of Weaning for Patients With Acute Brain Injury Undergoing Mechanical Ventilation
Led by Southeast University, China · Updated on 2025-11-18
406
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with acute brain injury (ABI) who often require intubation and invasive mechanical ventilation (IMV). This observational study aims to describe the outcomes of weaning these patients from mechanical ventilation and to identify factors that may predict successful weaning. The study responds to challenges faced due to high extubation failure rates in ABI patients compared to other critical care patients and the limited guidance available for managing weaning in this group. Participants will be observed during their ICU stay, focusing on the process of weaning from IMV. The study does not involve altering treatments but collects data to understand the weaning outcomes and extubation success over a 7-day period. The goal is to develop practical insights into weaning strategies tailored specifically for ABI patients. During the study, participants' progress will be monitored through their ICU medical records, focusing on whether they successfully wean from mechanical ventilation within seven days. Researchers will analyze clinical factors that might influence weaning success. The study involves no experimental interventions and follows participants through their ICU stay up to 7 days, with overall participation lasting as long as they remain in the ICU and under observation for weaning outcomes.
CONDITIONS
Brief Title
Weaning From Mechanical Ventilation in Patients With Acute Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute brain injury
- Age 18 years or older
- Invasive mechanical ventilation for at least 24 hours
You will not qualify if you...
- Tracheostomy before ICU admission
- Pregnant or lactating
- Cervical spinal cord injury
- Decision to receive palliative care within 24 hours of ICU admission
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 7 days (ICU stay)
Participants who are undergoing invasive mechanical ventilation due to acute brain injury are observed during their ICU stay to assess weaning success and extubation.
Daily assessments during ICU stay
Trial Site Locations
Total: 2 locations
1
Ling Liu
Nanjing, Jiangsu, China, 210009
Actively Recruiting
2
Department of Critical Care Medicine, Zhongda Hospital
Nanjing, China
Actively Recruiting
Research Team
L
Ling Liu, PHD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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