Actively Recruiting

Age: 18Years +
All Genders
ID06542107

Prediction of Weaning for Patients With Acute Brain Injury Undergoing Mechanical Ventilation

Led by Southeast University, China · Updated on 2025-11-18

406

Participants Needed

2

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying patients with acute brain injury (ABI) who often require intubation and invasive mechanical ventilation (IMV). This observational study aims to describe the outcomes of weaning these patients from mechanical ventilation and to identify factors that may predict successful weaning. The study responds to challenges faced due to high extubation failure rates in ABI patients compared to other critical care patients and the limited guidance available for managing weaning in this group. Participants will be observed during their ICU stay, focusing on the process of weaning from IMV. The study does not involve altering treatments but collects data to understand the weaning outcomes and extubation success over a 7-day period. The goal is to develop practical insights into weaning strategies tailored specifically for ABI patients. During the study, participants' progress will be monitored through their ICU medical records, focusing on whether they successfully wean from mechanical ventilation within seven days. Researchers will analyze clinical factors that might influence weaning success. The study involves no experimental interventions and follows participants through their ICU stay up to 7 days, with overall participation lasting as long as they remain in the ICU and under observation for weaning outcomes.

CONDITIONS

Brief Title

Weaning From Mechanical Ventilation in Patients With Acute Brain Injury

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Acute brain injury
  • Age 18 years or older
  • Invasive mechanical ventilation for at least 24 hours
Not Eligible

You will not qualify if you...

  • Tracheostomy before ICU admission
  • Pregnant or lactating
  • Cervical spinal cord injury
  • Decision to receive palliative care within 24 hours of ICU admission

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Monitoring

Duration - Up to 7 days (ICU stay)

Participants who are undergoing invasive mechanical ventilation due to acute brain injury are observed during their ICU stay to assess weaning success and extubation.

Daily assessments during ICU stay

Trial Site Locations

Total: 2 locations

1

Ling Liu

Nanjing, Jiangsu, China, 210009

Actively Recruiting

2

Department of Critical Care Medicine, Zhongda Hospital

Nanjing, China

Actively Recruiting

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Research Team

L

Ling Liu, PHD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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