Actively Recruiting
Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke
Led by Northwestern University · Updated on 2026-04-08
96
Participants Needed
1
Research Sites
480 weeks
Total Duration
On this page
Sponsors
N
Northwestern University
Lead Sponsor
S
Shirley Ryan AbilityLab
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of the study is to explore the feasibility of using a wearable device, called a myoelectric-computer interface (MCI), to improve arm movement in people who have had a stroke. Impaired arm movement after stroke is caused not just by weakness, but also by impaired coordination between joints due to abnormal co-activation of muscles. These abnormal co-activation patterns are thought to be due to abnormal movement planning.The MCI aims to reduce abnormal co-activation by providing feedback about individual muscle activations. This randomized, controlled, blinded study will test the home use of an MCI in chronic and acute stroke survivors.
CONDITIONS
Official Title
Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chronic stroke with hemiparesis from first-ever stroke at least 6 months before screening
- Severe motor impairment with Fugl-Meyer Assessment (FMA) score between 7 and 30
- Some voluntary activation of shoulder and elbow muscles
- Acute stroke with hemiparesis from first-ever stroke within the past 21 days
- Severe motor impairment with FMA score between 3 and 20 or Manual Motor Score of 1-8 in Shoulder Abduction and Finger Extensors
You will not qualify if you...
- Cognitive impairment causing moderately impaired attention or inability to follow MCI task instructions
- Visual impairments such as hemianopia preventing full view of the screen
- Anesthesia or neglect in affected arm or visual hemineglect (score of 2 on NIH Stroke Scale Extinction and Inattention subtest)
- Participation in another study involving the affected arm within 6 weeks or any pharmacological study
- Inability to understand or follow commands in English due to aphasia or other reasons
- Diffuse or multifocal brain infarcts
- Substantial arm pain preventing participation for 90 minutes daily
- Recent spasticity treatment including pharmacological or Botox interventions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
M
Marc W Slutzky, MD, PhD
CONTACT
C
Cynthia Gorski
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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