Actively Recruiting
Early Detection of Atypical Neuromuscular Development Using Wearable Sensors and Video: A Comparative Analysis of Muscle and Motion
Led by Shirley Ryan AbilityLab · Updated on 2026-03-25
40
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
S
Shirley Ryan AbilityLab
Lead Sponsor
A
Ann & Robert H Lurie Children's Hospital of Chicago
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to evaluate whether wearable sensor technology can be used to assess muscle activity and detect unusual muscle tone in infants up to 48 weeks postmenstrual age, which is about 8 weeks corrected age. The study focuses on neuromuscular development and muscle tone in young infants to better understand early muscle activation patterns. The sensors used are placed on the skin's surface and record data about the infant's body movements and muscle activity. Infants are grouped as those with typical muscle tone and those with low muscle tone. The study observes infants hospitalized in the NICU or well newborn nursery and collects data before the infants reach 8 weeks corrected age. Participants will have muscle tone evaluations, including electromyography (EMG) data and clinical scores, recorded and analyzed. Researchers will look for correlations between sensor data and observed muscle tone. The study involves assessments before 8 weeks corrected age and requires consent from legal guardians. The total study duration spans from enrollment to the final measurements within this early infancy period.
CONDITIONS
Brief Title
Wearable Sensors to Detect Atypical Muscle Activation in Young Infants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For infants with low tone: hospitalized in the NICU
- For low tone infants: greater than 38 weeks post-menstrual age
- For low tone infants: abnormal brain imaging or Apgar score less than 7 at five minutes with umbilical cord pH less than 7.15 if obtained
- For low tone infants: two or more warning signs for muscle tone or posture using the HNNE short form
- For infants with typical tone: born at 38 to 41 weeks of gestation
- For typical tone infants: hospitalized after birth in NICU or well newborn nursery
- For typical tone infants: appropriate gestational age birth weight
- For typical tone infants: normal HNNE exam with no warning signs
- Legal guardian able and willing to give written consent and comply with study procedures
You will not qualify if you...
- Infants with missing or incomplete limbs
- Infants with open wounds or skin breakdown on limbs or torso
- Infants with known genetic syndromes or congenital anomalies requiring surgery or affecting function
- Use of sedative medications (may include phenobarbital if level stable and therapeutic)
- Legal guardian unable to give written consent and comply with study procedures
- Lack of medical clearance from a physician if receiving inpatient care
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Before 8 weeks corrected age
Participants are observed using wearable sensors and video to detect atypical neuromuscular development.
1 to 2 visits depending on infant's condition
Trial Site Locations
Total: 2 locations
1
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
2
Shirley Ryan AbilityLab
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
R
Rachel Andersen
M
Megan O'Brien, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here