Actively Recruiting
A 44-week Monocentric Open Study Assessing the Efficacy and Safety of Deucravacitinib in Adults With Inflammatory Genodermatoses
Led by Centre Hospitalier Universitaire de Nice · Updated on 2025-08-05
10
Participants Needed
2
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn about deucravacitinib treatment in adults with inflammatory epidermal genodermatoses . The main question it aims to answer are: describe efficacity and safety of this treatment. Participants will take treatments and have to use bullets during the study period.
CONDITIONS
Official Title
A 44-week Monocentric Open Study Assessing the Efficacy and Safety of Deucravacitinib in Adults With Inflammatory Genodermatoses
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with congenital skin fragility showing skin or mucosal blisters and a confirmed diagnosis of Epidermolysis Bullosa Simplex by KRT5 and/or KRT14 mutation (autosomal only) or inflammatory ichthyosis including keratinopathic ichthyosis due to KRT1/10 mutation, or other identified genetic mutations like TGM5, NIPAL4, ABCA12
- Participants must have at least a mean daily number of 4 new blisters (for EBS-sev) or an Ichthyosis Severity Score (ISS) greater than 50 out of 128
- Agreement not to use any topical therapies other than those approved by the investigator
You will not qualify if you...
- Participants with other forms of inflammatory congenital ichthyosis such as Netherton syndrome or Kid syndrome
- Presence of infectious or immune-related conditions that exclude participation
- Relevant medical history or concurrent diseases that may interfere with the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
CHU de Nice
Nice, CHU de NICE, France, 06003
Actively Recruiting
2
APHP St Louis
Paris, France, France, 75010
Actively Recruiting
Research Team
C
christine chiaverini
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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