Actively Recruiting
A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.
Led by Pfizer · Updated on 2026-04-29
240
Participants Needed
54
Research Sites
72 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to learn about the safety and effects of the study medicine (called Ritlecitinib) for the possible treatment of hidradenitis suppurativa (HS). HS is a disease causing long lasting painful red skin lumps. This study is seeking participants who: * have moderate or severe HS * have previously received antibiotics for HS that did not help, or could not tolerate antibiotics Participants will be randomly (like a flip of coin) assigned to receive either the study medicine or a placebo (a pill that looks like the study medicine but does not contain any medicine). The study medicine or placebo will be taken by mouth once daily at home. For the first part of the study, participants will receive a loading (starting) dose. For the next part of the study, participants will receive a maintenance (ongoing) dose. Participants will take part in the study for about 24 weeks (about 6 months). There will be about 10 study clinic visits: a screening visit, Day 1, and then every 1, 2, or 4 weeks until week 16. At each visit, participants will report on their health and have tests such as physical exams, blood and urine tests, vital signs, chest X-rays, ECGs, hearing tests, and questionnaires. Participants will record when they take the study medicine and their HS symptoms every day in an eDiary on a mobile phone. The experiences of participants receiving the study medicine will be compared to those receiving placebo to help see if the study medicine is safe and effective.
CONDITIONS
Official Title
A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female participants aged 18 to 75 years
- Diagnosis of moderate to severe hidradenitis suppurativa for at least 6 months before screening
- Inadequate response to at least 4 weeks of oral antibiotics for hidradenitis suppurativa or intolerance to antibiotics
You will not qualify if you...
- Having 20 or more draining fistulae at screening or baseline visit
- Presence of other active skin diseases or conditions at screening
- Known immunodeficiency disorder
- History of systemic infection requiring hospitalization or intravenous treatment, including tuberculosis
- History of herpes zoster, hepatitis B, or hepatitis C infection
- Current or recent severe, progressive, or uncontrolled medical conditions
- Any medical or psychiatric condition including active suicidal thoughts in the past year or suicidal behavior in the past 5 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 54 locations
1
Medical Dermatology Specialists
Phoenix, Arizona, United States, 85006
Actively Recruiting
2
Burke Pharmaceutical Research
Hot Springs, Arkansas, United States, 71913
Actively Recruiting
3
First OC Dermatology Research Inc
Fountain Valley, California, United States, 92708
Not Yet Recruiting
4
Carbon Health - Urgent Care - La Habra
La Habra, California, United States, 90631
Not Yet Recruiting
5
Northridge Clinical Trials
Northridge, California, United States, 91325
Actively Recruiting
6
Wolverine Clinical Trials
Santa Ana, California, United States, 92706
Not Yet Recruiting
7
Skin Care Research
Boca Raton, Florida, United States, 33486
Not Yet Recruiting
8
Ziaderm Research LLC
North Miami Beach, Florida, United States, 33162
Not Yet Recruiting
9
D&H Tamarac Research Center
Tamarac, Florida, United States, 33321
Actively Recruiting
10
NMC Research LLC
Tampa, Florida, United States, 33607
Not Yet Recruiting
11
USF - Carol and Frank Morsani Center for Advanced Healthcare-Clinical Research Center
Tampa, Florida, United States, 33612
Not Yet Recruiting
12
Alliance Clinical Research of Tampa
Tampa, Florida, United States, 33615
Not Yet Recruiting
13
USF Florida Hearing Clinic
Tampa, Florida, United States, 33620
Not Yet Recruiting
14
TruDerm & TruSpa
Wellington, Florida, United States, 33449
Not Yet Recruiting
15
Advanced Medical Research, PC.
Sandy Springs, Georgia, United States, 30328
Not Yet Recruiting
16
Endeavor Health
Skokie, Illinois, United States, 60077
Not Yet Recruiting
17
Whisper Hearing Center
Indianapolis, Indiana, United States, 46240
Not Yet Recruiting
18
Dawes Fretzin Clinical Research Group, LLC
Indianapolis, Indiana, United States, 46250
Not Yet Recruiting
19
Community Imaging Center
Indianapolis, Indiana, United States, 46256
Not Yet Recruiting
20
The Indiana Clinical Trials Center, PC
Plainfield, Indiana, United States, 46168
Not Yet Recruiting
21
Options Research Group
West Lafayette, Indiana, United States, 47906
Actively Recruiting
22
Essential Medical Research - Overland Park
Overland Park, Kansas, United States, 66213
Actively Recruiting
23
Skin and Hair Center
Overland Park, Kansas, United States, 66213
Actively Recruiting
24
DS Research of Kentucky
Louisville, Kentucky, United States, 40241
Not Yet Recruiting
25
Revival Research Institute, LLC
Troy, Michigan, United States, 48084
Actively Recruiting
26
Skin Specialists, PC dba Schlessinger MD
Omaha, Nebraska, United States, 68144
Not Yet Recruiting
27
Stracskin
Portsmouth, New Hampshire, United States, 03801
Actively Recruiting
28
DJL Clinical Research, PLLC
Charlotte, North Carolina, United States, 28211
Not Yet Recruiting
29
ClinOhio Research Services
Columbus, Ohio, United States, 43213
Not Yet Recruiting
30
Columbia Dermatology & Aesthetics
Columbia, South Carolina, United States, 29212
Not Yet Recruiting
31
Palmetto Clinical Trial Services - Greenville
Greenville, South Carolina, United States, 29615
Not Yet Recruiting
32
Eurofins CRL
Forest, Virginia, United States, 24551
Not Yet Recruiting
33
Laser Rejuvenation Clinics Edmonton D.T. Inc
Edmonton, Alberta, Canada, T5J 3S9
Not Yet Recruiting
34
CaRe Clinic
Red Deer, Alberta, Canada, T4P 1K4
Actively Recruiting
35
Ryan Clinical Research Inc.
Newmarket, Ontario, Canada, L3Y 5G8
Actively Recruiting
36
DAR Clinical Research
Ottawa, Ontario, Canada, K1V 1C1
Not Yet Recruiting
37
North York Research Inc
Toronto, Ontario, Canada, M2N 3A6
Not Yet Recruiting
38
FACET Dermatology
Toronto, Ontario, Canada, M4E 1R7
Actively Recruiting
39
Centre de Recherche Saint-Louis inc.
Québec, Canada, G1W 4R4
Not Yet Recruiting
40
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
Dresden, Saxony, Germany, 01307
Not Yet Recruiting
41
Universitätsklinikum Schleswig-Holstein
Lübeck, Schleswig-Holstein, Germany, 23538
Not Yet Recruiting
42
Universitätsklinikum Frankfurt
Frankfurt, Germany, 60590
Not Yet Recruiting
43
Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska
Wroclaw, Lower Silesian Voivodeship, Poland, 50-566
Not Yet Recruiting
44
Centrum Badan Klinicznych PI-House sp. z o.o.
Gdansk, Poland, 80-546
Not Yet Recruiting
45
Centrum Zdrowia Dziecka i Rodziny im Jana Pawla II w Sosnowcu
Sosnowiec, Poland, 41-200
Not Yet Recruiting
46
Twoja Przychodnia Szczecinskie Centrum Medyczne Sp. z o.o.
Szczecin, Poland, 71-500
Not Yet Recruiting
47
Trialmed CRS - Warszawa
Warsaw, Poland, 02-482
Not Yet Recruiting
48
Państwowy Instytut Medyczny MSWiA
Warsaw, Poland, 02-507
Not Yet Recruiting
49
Klinika Ambroziak Dermatologia
Warsaw, Poland, 02-953
Not Yet Recruiting
50
Royalderm Agnieszka Nawrocka
Warsaw, Poland, 02-962
Not Yet Recruiting
51
Soft Skin Medical Center Dr Elzbieta Wojtowicz-Prus
Wroclaw, Poland, 50-551
Not Yet Recruiting
52
Hospital Universitario Puerta del Mar
Cadiz, Spain, 11009
Actively Recruiting
53
Hospital Universitario Virgen Nieves
Granada, Spain, 18014
Not Yet Recruiting
54
CHOP-Centro De Especialidades De Mollabao
Pontevedra, Spain, 36001
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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