Actively Recruiting
Weekly Sirolimus Therapy
Led by Medical University of South Carolina · Updated on 2026-03-05
24
Participants Needed
1
Research Sites
306 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In current practice, options for venous and lymphatic malformations remain limited. Recently an oral medication, sirolimus, has been found to benefit patients when taken once or twice a day for several months. Unfortunately there are many side effects associated with this medication, some of which can be severe including, neutropenia, oral ulcerations, and lab abnormalities. The purpose of this study is to determine if once weekly dosed sirolimus will be effective for the treatment of venous and lymphatic malformations. Additionally, the study will evaluate patient satisfaction and identify adverse effects. Participants will be on the medication for 6 months with an option to continue after this time period.
CONDITIONS
Official Title
Weekly Sirolimus Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient 2 years of age and older
- Diagnosis of venous, lymphatic, or venolymphatic malformations
You will not qualify if you...
- Children with contraindication to use of sirolimus
- Children with history of transplant
- Children with a history of natural immunodeficiency
- Children with a history of artificially induced immunodeficiency
- Children with a history of a serious or life-threatening infection
- Children taking CYP3A4 inhibiting medications
- Children taking strong CYP3A4 inducers to avoid subtherapeutic dosing/exposure
- Inability or unwillingness of subject or legal guardian/representative to give informed consent
- Women who are pregnant or may become pregnant; women of childbearing potential must use effective contraception before, during, and for 12 weeks after therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29403
Actively Recruiting
Research Team
S
Stephnie Munie, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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