Actively Recruiting
Weight Loss and CLOCK 3111T/C Polymorphism
Led by Hacettepe University · Updated on 2025-04-27
400
Participants Needed
1
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to investigate the relationship of CLOCK 3111T/C (rs1801260) gene variant with nutritional habits, nutritional status, chronotype, sleep quality, some biochemical parameters in overweight or obese individuals and to observe its effect on weight loss diet intervention. The main questions it aims to answer are: * Is the frequency of carrying the CLOCK 3111T/C (rs1801260) gene risk allele different between individuals with normal body weight and those who are overweight or obese? * Do those with the CLOCK 3111T/C (rs1801260) risk allele have a higher frequency of evening chronotype and a shorter sleep duration? * Is the effect of CLOCK 3111T/C (rs1801260) gene alleles different on weight loss diet response in overweight or obese individuals? A questionnaire will be applied to the individuals in both groups (normal body weight and overweight/obese individuals) to evaluate their general characteristics, eating habits, adherence to Mediterranean diet, DASH and MIND. In addition, anthropometric measurements, 3-day food consumption record and 3-day physical activity record will be taken from individuals. CLOCK 3111T/C (rs1801260) gene variant analysis in whole blood, adiponectin and leptin hormones in serum samples will be studied. Participants those who are overweight/obese will be asked to follow a weight loss diet for 3 months. Researchers will compare participants with normal body weight and those who are overweight or obese to see if there is a difference between the frequency of carrying the CLOCK 3111T/C (rs1801260) gene risk allele.
CONDITIONS
Official Title
Weight Loss and CLOCK 3111T/C Polymorphism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be between 20 and 50 years old
- Have a BMI between 25 and 40 kg/m2 for the overweight/obese group
- Have a BMI between 18.5 and 24.9 kg/m2 for the normal weight control group
You will not qualify if you...
- Have type 1 diabetes
- Use insulin therapy or oral diabetes medication for type 2 diabetes
- Use drugs for weight loss
- Have unstable cardiovascular disease
- Have kidney or liver failure
- Have diagnosed malabsorption conditions such as celiac disease, Crohn's disease, or ulcerative colitis
- Have undergone bariatric surgery
- Are pregnant or breastfeeding
- Are menopausal women
- Use corticosteroids
- Have severe endocrine disorders like hypothyroidism, hyperthyroidism, or hypopituitarism
- Have psychiatric or neurological diseases
- Experienced weight change greater than 5% in the last 6 months
- Have malignant tumors
- Have eating disorders
- Are shift workers
- Are relatives of other participants
- Belong to different ethnic backgrounds
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hacettepe University
Ankara, Turkey (Türkiye), 06050
Actively Recruiting
Research Team
H
Hande Gül Ulusoy Gezer, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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