Actively Recruiting
Weight Loss Via Intelligent Guidance in Patients With Coronary Heart Disease and Obesity: a Randomized Clinical Trial
Led by Guangdong Provincial People's Hospital · Updated on 2026-05-12
140
Participants Needed
1
Research Sites
141 weeks
Total Duration
On this page
Sponsors
G
Guangdong Provincial People's Hospital
Lead Sponsor
Y
Yuebei People's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Coronary Heart Disease (CHD) is an ischemic heart disease caused by coronary atherosclerosis, and it is the leading cause of death from cardiovascular diseases worldwide. Weight loss in obese patients can significantly improve metabolic indicators such as dyslipidemia and insulin resistance; therefore, weight loss may become a target for improving the prognosis of obese patients with coronary heart disease. This study is a multicenter, randomized controlled clinical trial aimed at evaluating the effect of software-based healthy weight loss guidance (personalized diet + exercise intervention) in obese patients with coronary heart disease. It is expected that 136 patients will be enrolled in hospitals including Guangdong Provincial People's Hospital, with a total study duration of 1 year.
CONDITIONS
Official Title
Weight Loss Via Intelligent Guidance in Patients With Coronary Heart Disease and Obesity: a Randomized Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years old
- Diagnosed coronary heart disease confirmed by coronary angiography or coronary CTA showing 50% or more narrowing in a major coronary artery, or history of myocardial infarction or coronary revascularization
- Body Mass Index (BMI) of 28 kg/m8 or higher
- Willingness to lose weight
- Ability to use a smartphone
- Capable of performing basic daily activities independently
- Voluntarily agree to participate and provide written informed consent
You will not qualify if you...
- Unstable angina or acute myocardial infarction within the past month
- Endocrine or neurological diseases, cancer, or history of weight-impacting surgery or medications
- Diseases limiting exercise ability such as severe heart/lung conditions or osteoarthritis
- Conditions affecting diet like severe mental disorders, eating disorders, or cognitive dysfunction
- Significant liver or kidney problems or dialysis treatment
- Severe disabilities preventing study participation
- Pregnancy, lactation, or unwillingness to use contraception if of childbearing potential
- Participation in other clinical trials
- Weight changed by more than 5% in the past year
- Habit of long-term high-intensity exercise
- Deemed unsuitable by researchers for participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China, 510080
Actively Recruiting
Research Team
Y
yuan yu, doctor
CONTACT
L
li huiyang, graduate student
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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