Actively Recruiting
Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma
Led by Xiaojun Chen · Updated on 2025-08-11
89
Participants Needed
1
Research Sites
252 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To investigate the efficacy of weight management plus megestrol acetate in obese patients with early endometrioid carcinoma（EEC）asking for fertility-sparing treatment
CONDITIONS
Official Title
Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 45 years
- Body mass index (BMI) of 24 kg/m2 or higher
- Signed informed consent
- Pathologically confirmed diagnosis of grade 1 endometrioid carcinoma of the endometrium
- Imaging (enhanced pelvic MRI and upper abdominal CT) within 2 weeks before treatment showing cancer confined to the endometrium without muscle or extrauterine invasion
- Strong desire for fertility preservation or desire to keep the uterus despite no reproductive plans
- Willingness and ability to comply with follow-up visits at Obstetrics and Gynecology Hospital of Fudan University
You will not qualify if you...
- Non-endometrioid or grade 2/3 endometrioid endometrial carcinoma or other reproductive system cancers
- Imaging showing myometrial invasion, cervical involvement, or spread beyond uterus
- Severe medical conditions or liver/kidney dysfunction (ALT/AST elevated ≥3 times normal, creatinine clearance <30 mL/min)
- Breast cancer or other hormone-dependent tumors incompatible with progesterone use
- Use of high-dose progestin or oral contraceptives within last 3 months
- Need for hysterectomy or other non-conservative treatments
- Known or suspected pregnancy
- Contraindications to progestin use
- History of deep vein thrombosis, stroke, or heart attack
- Severe joint problems preventing walking or movement
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Obstetrics and Gynecology Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200011
Actively Recruiting
Research Team
W
WEIWEI SHAN, PhD
CONTACT
X
XIAOJUN CHEN, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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