Actively Recruiting
Well-Formulated Ketogenic Diet Polycystic Kidney Disease
Led by Ohio State University · Updated on 2026-05-14
20
Participants Needed
1
Research Sites
147 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective study to determine ketogenic diet effect on htTKV, GFR, microalbuminuria. This is a single-center study of 20 patients with ADPKD and deemed high risk for progression to ESRD. This determined by combination of features of ADPKD and htTKV as assessed by prior computed tomography (CT) or MRI. Patients will be recruited from the Polycystic Kidney Disease (PKD) Clinic at Ohio State University Wexner Medical Center. Enrolled patients will have MRI for htTKV, urinary studies, blood tests at baseline, 6 months, and 52 weeks. Blood for GFR will be assessed three times over the course of the study including baseline, 6 months, and 1 year. Participants will follow ketogenic diet for 52 weeks. Investigatory diet team will manage the ketogenic diet.
CONDITIONS
Official Title
Well-Formulated Ketogenic Diet Polycystic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65 years old
- Diagnosis of ADPKD by imaging and/or genetic testing
- Glomerular filtration rate (GFR) 65 25 mg/dl
- At risk for rapid progression of ADPKD: Mayo Class 1C-1E with other high risk features such as early decline in GFR, hypertension onset 1 35 years, urologic events 1 35 years, PKD 1 truncating mutation, or PROPKD score 64
- No medication changes in the last three months
- Able to comply with the ketogenic diet
- Able to sign informed consent
You will not qualify if you...
- Currently treated with Tolvaptan
- Diagnosed with diabetes
- Pregnant
- Contraindications to MRI
- Used ketogenic diet in the last three months
- Severe kidney disease with GFR < 25 mg/dl
- Unable to purchase food for the diet
- Gastrointestinal disorders interfering with diet
- Chronic alcohol or drug abuse
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
M
Madison L Kackley, PhD
CONTACT
J
Jeff Volek, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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