Actively Recruiting
Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly
Led by Beijing Anzhen Hospital · Updated on 2026-02-11
182
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The WISER-AF trial is a multicenter, double-blind, sham-controlled, randomized controlled trial. It aims to evaluate the efficacy and safety of catheter ablation compared to a sham procedure in improving the quality of life (SF-36 score) in very elderly patients (aged ≥80 years) with symptomatic atrial fibrillation over a 6-month follow-up period.
CONDITIONS
Official Title
Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 80 years or older
- Documented paroxysmal or persistent atrial fibrillation by ECG or Holter within 6 months prior to enrollment
- Symptomatic atrial fibrillation including palpitations, chest tightness, fatigue, dizziness, blackouts, or shortness of breath
- Voluntary participation with signed informed consent
You will not qualify if you...
- New York Heart Association Class IV heart failure
- Acute myocardial infarction, cardiac surgery, or percutaneous coronary intervention within the past year
- Long-standing persistent atrial fibrillation lasting longer than 1 year
- Left atrial anteroposterior diameter greater than 6 cm
- History of prior atrial fibrillation ablation
- Atrial fibrillation caused by reversible conditions such as post-surgery, infection, or hyperthyroidism
- Severe mitral stenosis
- Moderate to severe liver failure (Child-Pugh class B or C)
- Severe kidney failure (stage 4 or 5) or ongoing dialysis
- Inability to cooperate due to dementia or severe mental disorder
- Presence of left atrial thrombus
- Previous left atrial appendage occlusion
- Contraindications to anticoagulation
- Life expectancy less than 1 year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Beijing, China
Actively Recruiting
Research Team
L
Liu He, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here