Actively Recruiting
Wether VNS in Early Stage (3 Months) is Safe and More Beneficial for Post-stroke Motor Rehabilitation
Led by Qilu Hospital of Shandong University · Updated on 2025-04-22
100
Participants Needed
1
Research Sites
86 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts. In previous study, Vagus nerve stimulation was constricted to patients 9 months after stroke. In this randomized phase I trial, we would apply vagus nerve stimulation in an early stage (\<6 month) and observe its theraputic effect on motor function after ischaemic Stroke.We hypothesized that the early stimulation could be safe and more beneficial compared to stimulation in late stage.
CONDITIONS
Official Title
Wether VNS in Early Stage (3 Months) is Safe and More Beneficial for Post-stroke Motor Rehabilitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- First-time, one-sided ischemic stroke in the middle cerebral artery area 3 to 36 months before surgery
- Moderate to severe upper limb weakness with FM-UE score of 42 or less
- Enough upper limb movement to take part in rehabilitation (score of 1 or more on FM-UE elbow flexion, extension, or finger movements)
You will not qualify if you...
- Severe stiffness or contractures in upper limb muscles (Modified Ashworth Scale = 4)
- Severe cognitive impairment (Mini Mental State Examination score less than 24)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250100
Actively Recruiting
Research Team
C
Chao Zhang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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