Actively Recruiting
What is Optimal Post-operative Prophylactic Therapy in Irradiated Breasts Undergoing Repeat Surgery
Led by University of Alberta · Updated on 2025-09-05
105
Participants Needed
2
Research Sites
183 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will look at whether females who have previously had breast surgery and radiation and are undergoing repeat breast surgery require any post operative interventions. The reason the investigators are conducting this study is because females who have undergone breast radiation are at higher risk of wound complications following breast surgery. The investigators will randomize recruited female participants into three arms, one which is post operative antibiotics for one week, one which is a wound VAC, and one which is no intervention. The investigators goal is to identify whether these patients will require any postoperative interventions.
CONDITIONS
Official Title
What is Optimal Post-operative Prophylactic Therapy in Irradiated Breasts Undergoing Repeat Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female
- Over 18 years of age
- Previous breast surgery and ipsilateral breast irradiation
- Requiring repeat breast surgery
You will not qualify if you...
- Male
- Under 18 years of age
- Currently on antibiotic therapy for other indications
- Known hypersensitivity to trimethoprim or sulfonamides
- History of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides
- Documented megaloblastic anemia due to folate deficiency
- Currently pregnant or breastfeeding
- Marked hepatic damage
- Severe renal insufficiency
- Severe sensitivity or allergy to silicone adhesive
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Meadowlark Health Centre
Edmonton, Alberta, Canada, T5R 5W9
Actively Recruiting
2
St Thomas Surgical Clinic
St. Albert, Alberta, Canada, T8N 7J6
Actively Recruiting
Research Team
M
Mahmoud, BHSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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