ORTHOSPINE FITNESS Study on Musculoskeletal Health Markers to Understand Complications in Degenerative Spinal Surgery

What this Trial Is About

Researchers are investigating markers of musculoskeletal health to understand complications in spinal surgery for patients with degenerative diseases of the thoraco-lumbo-sacral spine. This multicenter study, funded by the European Union and the Ministry of Health, aims to address the significant problem of surgical complications, which occur in 7 to 20% of cases and impact both patients and healthcare systems. The goal is to improve surgical decisions and reduce adverse events by identifying important health markers. The study involves comprehensive preoperative screening combining advanced imaging techniques, including HRpQCT scans to assess bone microstructure and computational analysis of bone strength. It also evaluates physical fragility by measuring muscle strength and balance, along with cellular and molecular tests of bone and muscle interaction, and nutritional assessments. These evaluations will help define surgical suitability and guide patient-specific interventions such as nutritional support or physical preparation before surgery. Participants will undergo assessments including radiological imaging, collection of biological samples at baseline, six months, and twelve months, and evaluations of pain, quality of life, and nutritional status over two weeks from the start. The study tracks these measures to understand their relationship with post-surgical complications. Participation lasts at least 12 months, with follow-up visits to monitor outcomes and support surgical decision-making.

Which Markers of Musculoskeletal Health Can Explain Complications in Spinal Surgery?