Actively Recruiting
White Matter Plasticity in Schizophrenia
Led by University of Maryland, Baltimore · Updated on 2026-02-20
36
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.
CONDITIONS
Official Title
White Matter Plasticity in Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
- Age between 15 and 45 years
- Able to provide informed consent
You will not qualify if you...
- Contraindications to MRI such as metal implants or claustrophobia
- Medical conditions limiting hand use, for example arthritis
- Active or recent (within 6 months) substance use disorder other than nicotine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Maryland Psychiatric Research Center
Catonsville, Maryland, United States, 21228
Actively Recruiting
2
University of Maryland Baltimore - Maryland Psychiatric Research Center
Catonsville, Maryland, United States, 21228
Not Yet Recruiting
Research Team
J
Joshua J Chiappelli, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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