Actively Recruiting
Study of Brain White Matter Changes in Schizophrenia Using a Music Video Game
Led by University of Maryland, Baltimore · Updated on 2026-02-20
36
Participants Needed
2
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Schizophrenia spectrum disorders involve damage to the white matter in the brain, which is important for quick communication between brain regions needed for complex thinking. This damage is linked to difficulties with thinking skills in schizophrenia, especially slower processing speed. The study aims to explore whether training by playing a mock musical instrument can improve white matter structure in people with these disorders. Participants will be randomly assigned to one of two groups. One group will take part in training sessions using the video game Guitar Hero to learn a new skill, while the other group will have observation training. The study will compare changes in white matter microstructure and brain levels of N-acetylaspartate over a 3-week period. Throughout the study, participants will be evaluated using brain scans and other assessments to measure changes in white matter and brain chemistry. The main outcome is the change in white matter microstructure after 3 weeks. Participants will be monitored for safety and adherence during the study, which runs from January 2025 to December 2026, with involvement lasting at least 3 weeks.
CONDITIONS
Brief Title
White Matter Plasticity in Schizophrenia
Research Team
J
Joshua J Chiappelli, MD
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