Actively Recruiting
Who Will Benefit From Bariatric Surgery for Diabetes?
Led by Imperial College London · Updated on 2023-04-19
210
Participants Needed
1
Research Sites
522 weeks
Total Duration
On this page
Sponsors
I
Imperial College London
Lead Sponsor
N
National Institute for Health Research, United Kingdom
Collaborating Sponsor
AI-Summary
What this Trial Is About
A study investigating the influence of fat distribution, genetic susceptibility markers for type 2 diabetes (T2DM) and fat distribution, epigenetic and transcriptomic changes and gut hormone responses to a mixed meal on diabetes remission following bariatric surgery.
CONDITIONS
Official Title
Who Will Benefit From Bariatric Surgery for Diabetes?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Planning to undergo Roux-en-Y gastric bypass surgery
- Age between 18 and 80 years
- Diagnosis of type 2 diabetes mellitus or prediabetes
- Stable weight for at least 3 months
- Obese with body mass index of 30 kg/m2 or higher
- Eligible for surgery under National Health Service criteria
- Healthy volunteers aged 18-80 years
- Healthy volunteers with body mass index between 19 and 25 kg/m2
- Healthy volunteers with stable weight for at least 3 months
You will not qualify if you...
- Current pregnancy
- Unable to give informed consent
- Type 1 diabetes
- Low fasting C-peptide levels
- Secondary diabetes or absence of beta-cell function
- Unable to undergo DEXA scan or conditions affecting body fat composition such as cirrhosis, ascites, or malignancy
- Current smoker
- Participation in another interventional trial within the last 3 months
- Unable to understand English
- Abnormal glucose tolerance or fasting glucose in healthy volunteers
- Medical conditions or medication use interfering with study participation in healthy volunteers
- Lack of telephone access or other factors interfering with study participation
- Breastfeeding
- Unable to maintain adequate contraception during the study
- Blood donation in last 3 months or planned during study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Imperial College Healthcare NHS Trust
London, Greater London, United Kingdom, W12 0HS
Actively Recruiting
Research Team
J
Julia S Kenkre, MB BChir
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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