The Enigma of Subjective Lymphedema: Who and Why do Patients Report Lymphedema After Breast Cancer Treatment Without an Objective Measurable Swelling? The Role of Lymphatic and Sensory Processing Problems

What this Trial Is About

Breast cancer related lymphedema (BCRL) affecting the arm and/or trunk is a serious complication after breast cancer treatment due to its long-lasting effects and impact on quality of life. Although the occurrence of objective BCRL has decreased with changes in breast cancer treatment, many patients still report a feeling of swelling without measurable BCRL, called subjective BCRL. Researchers aim to study the prevalence, transitions, and underlying mechanisms of subjective BCRL, focusing on lymphatic and sensory processing problems in breast cancer patients after surgery. This study involves breast cancer patients scheduled for surgery with either axillary lymph node dissection or sentinel node biopsy. Participants will undergo various clinical assessments to measure different types of BCRL at the arm and trunk/breast using volumetric measurements, bioimpedance, ultrasonography, lymphofluoroscopy, and sensory testing devices. These assessments will evaluate swelling, lymphatic function, and sensory problems at 1, 6, and 12 months after surgery to better understand the factors linked to subjective BCRL. Participants will be monitored over a year post-surgery through questionnaires and clinical tests assessing swelling, tissue changes, sensory loss, pain, muscle stiffness, and body perception. The study measures the presence and severity of both subjective and objective BCRL and related sensory impairments. This detailed follow-up includes physical exams, imaging, and sensory evaluations to track changes and identify contributing factors. The total participation duration is 12 months after surgery, with safety and outcome monitoring throughout this period.

Who and Why do Patients Report Lymphedema After Breast Cancer Treatment Without an Objective Measurable Swelling