Study of Skin Damage in Wilsons Disease Patients Treated With D-Penicillamine Using Silicone Molds to Measure Skin Elasticity Compared to Healthy Volunteers

What this Trial Is About

Wilsons disease is a genetic condition caused by a mutation in the ATP7B gene, leading to harmful copper buildup in organs like the liver, nervous system, and eyes. This buildup causes liver and neurological problems. The usual treatment is D-Penicillamine, which helps remove copper through urine but can cause skin side effects. The exact cause of skin damage in these patients is not fully understood and needs more study to improve treatment approaches. Researchers are studying skin damage in Wilsons disease patients treated with D-Penicillamine by making silicone molds of the skins surface on patients forearms. These molds will be analyzed using confocal laser technology and compared to those from healthy volunteers. The study includes two groups patients with Wilsons disease on D-Penicillamine and healthy individuals matched by age and sex. Participants will have skin tension measured at the start of the study and again after one year using silicone casts and confocal laser methods. The study involves preparation of forearm molds with a special silicone product. Researchers will monitor skin elasticity changes over time and compare findings between treated patients and healthy controls. The total duration includes initial measurements and follow-up at one year to assess skin condition changes.

Wilson's Disease Treated With D-Penicillamine: Characterization of Skin Damage Secondary to Treatment by Measuring Skin Elasticity