Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07013175

Wise Choices in the Intensive Care Unit

Led by Karolinska Institutet · Updated on 2025-12-02

10000

Participants Needed

2

Research Sites

112 weeks

Total Duration

On this page

Sponsors

K

Karolinska Institutet

Lead Sponsor

U

Uppsala-Örebro Regional Research Council

Collaborating Sponsor

AI-Summary

What this Trial Is About

Aim: to evaluate if the Choosing Wisely campaign can be introduced without harming critically ill patients. Background: Each year, around 45,000 patients are admitted to Sweden's 81 ICUs (intensive care units), costing 6-7 billion SEK (6% of total healthcare expenditure). The high costs of health care are partly attributable to overuse of diagnostic tests. Up to 30% of these tests lead to treatments that provide no benefit for patients, some of them may even be harmful(1-3). To improve quality of care while combating this problem of cost, the American Board of Internal Medicine Foundation developed the Choosing Wisely Campaign, tasking professional societies to develop lists of top five medical services patients and physicians should question. Patients in the ICU, can especially benefit from this paradigm shift. They are subjected to multiple testing on a daily - sometimes hourly - basis, therefore this field of medicine responded to the campaign quickly. Two sets of top-five-lists of tests and interventions that can be questioned have been published(4 5). In multiple countries, including Sweden, the Choosing Wisely campaign is gathering traction among critical care physicians and is on the verge of being introduced. It is both common-sensical and will save money, so health care leaders are positive. However, the investigators have an opportunity, and a duty, to assess the evidence; can the Choosing Wisely campaign be introduced without harming ICU patients? The present study thus aims to evaluate the introduction of the Choosing Wisely campaign in the context of the ICU. Is this change of care strategy associated with changes in 30-day-mortality? Secondary outcomes include ICU length of stay, use of non-invasive- or invasive mechanical ventilation and continuous renal replacement therapy. This is a registry-based cluster randomized controlled study (R-RCT), targeting Swedish ICU's across multiple regions. Primary and secondary outcomes will be retrieved from the Swedish Intensive care Register (SIR), making ICU participation easier and less costly.

CONDITIONS

Official Title

Wise Choices in the Intensive Care Unit

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients 18 years or older, treated in Swedish ICU's
Not Eligible

You will not qualify if you...

  • Patients under the age of 18 years

AI-Screening

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Trial Site Locations

Total: 2 locations

1

Karolinska University Hospital

Stockholm, Sweden, 171 76

Actively Recruiting

2

Karolinska Institutet

Stockholm, Sweden

Actively Recruiting

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Research Team

M

Max B Bell, MD, PhD

CONTACT

E

Emma Larsson, MD, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

SEQUENTIAL

Primary Purpose

TREATMENT

Number of Arms

2

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