Actively Recruiting
WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)
Led by Mediar Therapeutics · Updated on 2026-05-06
164
Participants Needed
69
Research Sites
116 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A Phase 2a, Randomized, Double-blind, Placebo-Controlled Study of the Safety and Efficacy of MTX-463 in Participants with Idiopathic Pulmonary Fibrosis (IPF)
CONDITIONS
Official Title
WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with IPF of any gender aged 40 years or older at time of signing informed consent
- Able to understand the study and provide signed, written informed consent
- Able to read and understand the language of the informed consent and other trial materials
- Meet 2019 ATS/ERS/JRS/ALAT criteria for IPF diagnosis; diagnosed within 7 years of screening
- If on pirfenidone or nintedanib, dose must be stable for at least 90 days before screening and maintained during study; both agents cannot be used together
- If discontinued pirfenidone or nintedanib, must have stopped at least 30 days before screening and no plans to restart during study
- Forced vital capacity (FVC) of 45% predicted or higher at screening
- Diffusing capacity of the lungs for carbon monoxide (DLCO) of 25% predicted or higher at screening
- Willing and able to complete all required study visits and procedures
- Negative serum pregnancy test at screening for participants of childbearing potential
- Agree to use medically approved contraception during the study if of reproductive potential
You will not qualify if you...
- Acute exacerbation of IPF within 6 months before or during screening
- FEV1/FVC ratio less than 0.7 at screening
- Need for continuous supplemental oxygen (intermittent use allowed)
- Expected lung transplant during study period
- Current active bacterial lung infection or recent antibiotic use within 30 days before screening
- Planned surgery during study period
- Clinically significant pulmonary hypertension
- Use of immunosuppressive therapy (excluding corticosteroids) within required washout period
- Use of systemic corticosteroids at 10 mg or higher daily within 30 days before screening
- Current smoking or vaping
- Current or recent (within 2 years) malignancy or lymphoproliferative disorder, except certain skin cancers
- Current infection with hepatitis B, hepatitis C, or HIV
- Pregnancy, breastfeeding, or planning conception during study
- History of severe depression, psychosis, or suicidal thoughts within 2 years before screening
- Any significant disease or lab abnormality interfering with study participation or safety
- Elevated liver enzymes (AST or ALT more than twice the upper limit of normal) at screening
- Known allergy to MTX-463 or its components
- Prior use of MTX-463 or other WISP1-targeting therapies
- Use of other investigational agents without appropriate washout before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 69 locations
1
WISPer Site in Birmingham, AL
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
WISPer site in Phoenix, AZ
Phoenix, Arizona, United States, 85032
Actively Recruiting
3
WISPer Site in Los Angeles, CA
Los Angeles, California, United States, 90033
Actively Recruiting
4
WISPer site in Newport Beach, CA
Newport Beach, California, United States, 92663
Actively Recruiting
5
WISPer Site in Palm Springs, CA
Palm Springs, California, United States, 92203
Actively Recruiting
6
WISPer Site in Denver, CO
Denver, Colorado, United States, 80206
Actively Recruiting
7
WISPer site in Loxahatchee, FL
Loxahatchee Groves, Florida, United States, 33470
Actively Recruiting
8
WISPer Site in Atlanta, GA
Atlanta, Georgia, United States, 30322
Actively Recruiting
9
WISPer site in Champaign, IL
Champaign, Illinois, United States, 61822
Actively Recruiting
10
WISPer site in Kansas City, KS
Kansas City, Kansas, United States, 66160
Actively Recruiting
11
WISPer Site in Louisville, KY
Louisville, Kentucky, United States, 40202
Actively Recruiting
12
WISPer site in Shreveport, LA
Shreveport, Louisiana, United States, 71103
Actively Recruiting
13
WISPer Site in Baltimore, MD
Baltimore, Maryland, United States, 21224
Actively Recruiting
14
WISPer Site in Boston, MA
Boston, Massachusetts, United States, 02114
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15
WISPer Site in Ann Arbor, MI
Ann Arbor, Michigan, United States, 48209
Actively Recruiting
16
WISPer Site in Detroit, MI
Detroit, Michigan, United States, 48202
Actively Recruiting
17
WISPer site in New York, NY
New York, New York, United States, 10032
Actively Recruiting
18
WISPer Site in Durham, NC
Durham, North Carolina, United States, 27710
Actively Recruiting
19
WISPer site in Greensboro, NC
Greensboro, North Carolina, United States, 27403
Actively Recruiting
20
WISPer site in Oklahoma City, OK
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
21
WISPer Site in Pittsburg, PA
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
22
WISPer Site in Charleston, SC
Charleston, South Carolina, United States, 29425
Actively Recruiting
23
WISPer Site in Nashville, TN
Nashville, Tennessee, United States, 37204
Actively Recruiting
24
WISPer site in Dallas, TX
Dallas, Texas, United States, 75204
Actively Recruiting
25
WISPer Site in Salt Lake City, UT
Salt Lake City, Utah, United States, 84103
Actively Recruiting
26
WISPer Site in Wilwaukee, WI
Milwaukee, Wisconsin, United States, 52226
Actively Recruiting
27
WISPer Site in Buenos Aires, Argentina
Buenos Aires, Argentina, B1602DQD
Actively Recruiting
28
WISPer Site in Cordoba, Argentina
Córdoba, Argentina, X5003DCE
Actively Recruiting
29
WISPer Site in Mendoza, Argentina
Mendoza, Argentina, M5500
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30
WISPer Site in Rosario, Argentina
Rosario, Argentina, S2000DBS
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31
WISPer Site in San Miguel De Tucumán, Argentina
San Miguel de Tucumán, Argentina, T4000IAI
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32
WISPer Site in Santa Fe, Argentina
Santa Fe, Argentina, S2000DBS
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33
WISPer Site in Santa Fe, Argentina
Santa Fe, Argentina, S3000ASF
Actively Recruiting
34
WISPer site in Greenslopes, Australia
Greenslopes, Australia, 4120
Actively Recruiting
35
WISPer site in Melbourne, Australia
Melbourne, Australia, 3004
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36
WISPer site in Midland, Australia
Midland, Australia, 6056
Actively Recruiting
37
WISPer site in Westmead, Australia
Westmead, Australia, 2145
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38
WISPer Site in Brussels, Belgium
Brussels, Belgium, 1200
Actively Recruiting
39
WISPer Site in Edegem, Belgium
Edegem, Belgium, 2650
Actively Recruiting
40
WISPer Site in Belo Horizonte, Brazil
Belo Horizonte, Brazil, 30110
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41
WISPer Site in Curitiba, Brazil
Curitiba, Brazil, 80060
Actively Recruiting
42
WISPer Site in Passo Fundo, Brazil
Passo Fundo, Brazil, 99010
Actively Recruiting
43
WISPer Site in Porto Alegre, Brazil
Porto Alegre, Brazil, 90035
Actively Recruiting
44
WISPer Site in Porto Alegre, Brazil
Porto Alegre, Brazil, 90410
Actively Recruiting
45
WISP Site in São Bernardo Do Campo, Brazil
São Bernardo do Campo, Brazil, 09715
Actively Recruiting
46
WISPer Site in Sao Paulo, Brazil
São Paulo, Brazil, 05403
Actively Recruiting
47
WISPer Site in Calgary, Alberta
Calgary, Alberta, Canada, T2N 4Z5
Actively Recruiting
48
WISPer site in Ajax, ON
Ajax, Ontario, Canada, L1S 2J5
Actively Recruiting
49
WISPer site in Trois-Rivières, Quebec
Trois-Rivières, Quebec, Canada, G8T 7A1
Actively Recruiting
50
WISPer Site in Split
Split, Croatia, 21000
Actively Recruiting
51
WISPer Site in Nantes, France
Nantes, France, 44800
Actively Recruiting
52
WISPer Site in Nice, France
Nice, France, 06001
Actively Recruiting
53
WISPer Site in Paris, France
Paris, France, 75015
Actively Recruiting
54
WISPer Site in Rennes, France
Rennes, France, 35033
Actively Recruiting
55
WISPer Site in Abbotstown, Ireland
Abbotstown, Ireland, D15 X40D
Actively Recruiting
56
WISPer Site in Drogheda, Ireland
Drogheda, Ireland, F92VW28
Actively Recruiting
57
WISPer Site in Dublin, Ireland
Dublin, Ireland, D24 NR0A
Actively Recruiting
58
WISPer Site in Letterkenny, Ireland
Letterkenny, Ireland, F92 AE81
Actively Recruiting
59
WISPer Site in Nieuwegein, Netherlands
Nieuwegein, Netherlands, 3435CM
Actively Recruiting
60
WISPer Site in Barcelona, Spain
Barcelona, Spain, 08017
Actively Recruiting
61
WISPer Site in Barcelona, Spain
Barcelona, Spain, 08036
Actively Recruiting
62
WISPer Site in Lugo, Spain
Lugo, Spain, 27003
Actively Recruiting
63
WISPer Site in Madrid, Spain 2
Madrid, Spain, 28050
Actively Recruiting
64
WISPer Site in Madrid, Spain
Madrid, Spain, 28223
Actively Recruiting
65
WISPer Site in Santander, Spain
Santander, Spain, 39008
Actively Recruiting
66
WISPer Site in Birmingham, UK
Birmingham, United Kingdom, B15 2GW
Actively Recruiting
67
WISPer Site in Cambridge, UK
Cambridge, United Kingdom, CB2 0BB
Actively Recruiting
68
WISPer Site in Edinburgh, UK
Edinburgh, United Kingdom, EH16 4SA
Actively Recruiting
69
WISPer Site in Oxford, UK
Oxford, United Kingdom, OX3 7LE
Actively Recruiting
Research Team
J
Jeffrey Bornstein, MD
CONTACT
K
Katherine Palu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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