The Women's Ischemia Syndrome Evaluation (WISE) study: protocol design, methodology and feasibility report.
C N Merz, S F Kelsey, C J Pepine...
https://pubmed.ncbi.nlm.nih.gov/10334408Completed
Phase 3
Age: 15Years +
FEMALE
ID00000554
Led by University of Pittsburgh · Updated on 2014-04-04
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
To evaluate innovative diagnostic methods that will improve the diagnostic reliability of cardiovascular testing in evaluation of ischemic heart disease in women. Innovative approaches proposed include physiologic or functional measurements such as impaired metabolism, perfusion, or endothelial function as well as assessment of epicardial coronary arteries by angiography. Other objectives include developing safe, accurate, and cost effective diagnostic approaches for evaluating women with suspected ischemic heart disease, and determining the frequency of myocardial ischemia in the absence of significant epicardial coronary stenosis, as well as the frequency of non-ischemic or non-cardiac chest pain. A key aspect of the WISE study is to determine whether evidence of myocardial ischemia occurs in the absence of obstructive coronary disease.
CONDITIONS
Official Title
Women's Ischemia Syndrome Evaluation (WISE)
Who Can Participate
Age: 15Years +
FEMALE
Eligibility Criteria
You may qualify if you...
Women over the age of 18 who have suspected ischemic heart disease.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
DIAGNOSTIC
Number of Arms
0
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Published Research Related To This Trial
Coronary flow velocity response to adenosine characterizes coronary microvascular function in women with chest pain and no obstructive coronary disease. Results from the pilot phase of the Women's Ischemia Syndrome Evaluation (WISE) study.
S E Reis, R Holubkov, J S Lee...
https://pubmed.ncbi.nlm.nih.gov/10334410Dobutamine stress echocardiography in women with chest pain. Pilot phase data from the National Heart, Lung and Blood Institute Women's Ischemia Syndrome Evaluation (WISE).
J F Lewis, L Lin, S McGorray...
https://pubmed.ncbi.nlm.nih.gov/10334409Effect of coronary angiography on use of lipid-lowering agents in women: a report from the Women's Ischemia Syndrome Evaluation (WISE) study. For the WISE Investigators.
V Bittner, M Olson, S F Kelsey...
https://pubmed.ncbi.nlm.nih.gov/10781756Physical activity and functional capacity measurement in women: a report from the NHLBI-sponsored WISE study.
C N Bairey Merz, M Olson, S McGorray...
https://pubmed.ncbi.nlm.nih.gov/11025869Weight cycling and high-density lipoprotein cholesterol in women: evidence of an adverse effect: a report from the NHLBI-sponsored WISE study. Women's Ischemia Syndrome Evaluation Study Group.
M B Olson, S F Kelsey, V Bittner...
https://pubmed.ncbi.nlm.nih.gov/11079659Psychosocial variables are associated with atherosclerosis risk factors among women with chest pain: the WISE study.
T Rutledge, S E Reis, M Olson...
https://pubmed.ncbi.nlm.nih.gov/11292277Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory).
B L Sharaf, C J Pepine, R A Kerensky...
https://pubmed.ncbi.nlm.nih.gov/11305981Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study.
S E Reis, R Holubkov, A J Conrad Smith...
https://pubmed.ncbi.nlm.nih.gov/11320360History of anxiety disorders is associated with a decreased likelihood of angiographic coronary artery disease in women with chest pain: the WISE study.
T Rutledge, S E Reis, M Olson...
https://pubmed.ncbi.nlm.nih.gov/11693752