Actively Recruiting
Woodsmoke Exposure, Influenza Infection, and Nasal Immunity
Led by University of North Carolina, Chapel Hill · Updated on 2026-04-30
112
Participants Needed
1
Research Sites
170 weeks
Total Duration
On this page
Sponsors
U
University of North Carolina, Chapel Hill
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will investigate the effects of woodsmoke (WS) exposure on human nasal mucosal immune responses to viral infection. The study tests the hypotheses that WS exposure modifies biomarkers of nasal mucosal immune function, increases in Live Attenuated Influenza Virus (LAIV) -induced nasal symptoms, and reduces mucosal antibody production.
CONDITIONS
Official Title
Woodsmoke Exposure, Influenza Infection, and Nasal Immunity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Normal lung function
- Oxygen saturation greater than 94%
- Normal blood pressure
- No respiratory symptoms and normal pulmonary exam
- Normal pulmonary function testing
- Age between 18 and 49 years
You will not qualify if you...
- History of significant chronic illnesses such as diabetes, autoimmune diseases, immunodeficiency, ischemic heart disease, chronic obstructive pulmonary disease, asthma, or hypertension
- Positive pregnancy test within 48 hours of challenge
- Use of any inhaled substance for medical or recreational purposes
- Nonsmokers must have abstained from smoking for the past 12 months and not smoked more than 1 pack in the past year
- Allergy to eggs
- Acute medical conditions like pneumonia or bronchitis requiring antibiotics or flu-like symptoms unresolved for at least 3 weeks
- Illnesses increasing risk from LAIV infection as judged by investigator
- Expected exposure to immunocompromised individuals within 3 weeks after LAIV inoculation
- Use of immunosuppressive drugs within the last 6 months
- Woodsmoke exposure within the past 3 weeks
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mary Ellen Jones
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
Research Team
C
Carole Robinette, MS
CONTACT
C
Chris Brooks
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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