Actively Recruiting
Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment
Led by University of Maryland, Baltimore · Updated on 2026-05-12
90
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The prevalence of dementia will double in the next three decades in the U.S.; effective treatment or prevention for dementia is urgently needed. The current exploratory project aims to evaluate and understand how the brain and cognition may improve after a 12-week intervention that combines brain training and aerobic exercise training to improve brain function, both in those with mild cognitive impairment (some with possible prodromal Alzheimer's disease) and with healthy aging. Findings from this pilot project will guide and refine the development of a future larger clinical trial that aligns with the goals of the National Alzheimer's Plan of Action (NAPA), especially regarding "Prevent and Effectively Treat Alzheimer's Disease (AD) by 2025.
CONDITIONS
Official Title
Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 50 to 80 years of all races and ethnicities
- Sedentary adults exercising less than three times per week for aerobic or combined training
- Ability to use and access an iPad or computer for cognitive training or combined training
- Fluent in English
- Diagnosis of mild cognitive impairment confirmed by clinical dementia rating scale and Montreal Cognitive Assessment
- Preserved independence in daily activities confirmed by caregiver interview and assessment
You will not qualify if you...
- No access to computer or internet for cognitive training and unwilling to come to the lab
- Unable to undergo MRI due to claustrophobia or metal foreign bodies
- Symptomatic heart disease, coronary artery disease, congestive heart failure, uncontrolled hypertension or diabetes, or other significant cardiovascular disorders preventing exercise
- Neurologic, musculoskeletal, or other conditions limiting physical assessments
- Estimated verbal IQ below 70 invalidating informed consent
- Moderate to severe substance use disorder
- Severe chronic or acute medical or neuropsychiatric conditions affecting cognition or brain imaging
- Body mass index over 40 kg/m2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Maryland Baltimore
Baltimore, Maryland, United States, 21201
Actively Recruiting
Research Team
L
Linda Chang, M.D., M.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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