Actively Recruiting
Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery
Led by University of Medicine and Pharmacy at Ho Chi Minh City · Updated on 2026-02-04
14
Participants Needed
1
Research Sites
38 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if triclosan-coated absorbable stitches (polyglactin 910 sutures coated with triclosan, an antibacterial agent) help soft tissue heal better and have fewer bacteria stuck to the stitches after lower impacted wisdom tooth surgery in adults aged 18 to 35 years. The main questions it aims to answer are: 1. Does triclosan-coated polyglactin 910 suture lead to better soft-tissue wound healing than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery? 2. Does triclosan-coated polyglactin 910 suture result in a lower oral bacterial load adhered to the suture material than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery? Participants will: * Have surgery to remove two similar lower impacted wisdom teeth (one on each side) * Receive triclosan-coated stitches on one side and standard stitches on the other side, with the side assignment chosen at random * Return for follow-up visits on day three, day five, and day seven after surgery for healing checks, simple ratings of pain and swelling, and collection of a small stitch sample for bacterial testing.
CONDITIONS
Official Title
Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 35 years
- American Society of Anesthesiologists (ASA) physical status I or II
- Presence of two symmetric impacted mandibular third molars with similar difficulty and less than 15 degrees difference in angulation
- No use of topical or systemic antibiotics for at least 4 weeks before surgery
- Able and willing to provide written informed consent
- No active infection related to the mandibular third molar at enrollment
You will not qualify if you...
- Pregnant or breastfeeding
- Allergy to local anesthetic (2% lidocaine with 1:100,000 epinephrine) or any medications used in the study
- Radiographic evidence of tumor or cyst associated with the impacted mandibular third molar
- Withdrawal of consent or unwillingness to continue participation
- Unable to attend scheduled follow-up visits
- Difference in surgical extraction time between procedures of 12 minutes or more
- Loss or loosening of sutures before final assessment
AI-Screening
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Trial Site Locations
Total: 1 location
1
Specialized Dental Clinic, University of Medicine and Pharmacy at Ho Chi Minh City
Ho Chi Minh City, Vietnam
Actively Recruiting
Research Team
L
Le Khanh Huyen Nguyen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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