Actively Recruiting
Evaluation of Soft Tissue Healing and Antibacterial Effectiveness of Triclosan-Coated Polyglactin 910 Sutures After Impacted Mandibular Third Molar Surgery: A Randomized Double-Blind Split-Mouth Clinical Trial
Led by University of Medicine and Pharmacy at Ho Chi Minh City · Updated on 2026-02-04
14
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying whether triclosan-coated absorbable stitches (polyglactin 910 sutures with an antibacterial coating) improve soft tissue healing and reduce bacterial presence compared to standard non-coated stitches after surgery to remove lower impacted wisdom teeth in adults aged 18 to 35 years. This randomized, double-blind, two-period crossover clinical trial aims to answer if the coated sutures lead to better healing and less bacteria on postoperative days 3, 5, and 7 after surgery. Each participant will have two separate surgeries spaced about 4 weeks apart to remove symmetrical lower impacted wisdom teeth, one on each side. During one surgery, triclosan-coated sutures will be used, and during the other, non-coated sutures will be used. The order of suture type is randomly assigned. Follow-up visits are scheduled on postoperative days 3, 5, and 7 after each surgery to evaluate healing, measure pain and swelling, and collect small suture samples for bacterial testing. Participants will be closely monitored during the first week after each surgery through clinical assessments and laboratory tests on the collected suture samples. The main measurement is the amount of bacteria on the sutures using real-time PCR. Secondary assessments include soft tissue healing scores and patient-reported pain and swelling levels. The crossover design allows comparison within each participant to reduce variability. Total participation includes two surgeries and multiple follow-up visits over about five weeks.
CONDITIONS
Brief Title
Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 35 years
- ASA physical status I or II
- Two symmetric impacted mandibular third molars with similar difficulty and angulation difference no more than 15 degrees
- No topical or systemic antibiotics used for at least 4 weeks before surgery
- Able and willing to provide written informed consent
- No active infection related to the mandibular third molar at enrollment
You will not qualify if you...
- Pregnant or breastfeeding
- Allergy to local anesthetic or any study medications
- Radiographic signs of tumor or cyst near the impacted mandibular third molar
- Withdrawal of consent or refusal to continue participation
- Unable to attend scheduled follow-up visits
- Surgical extraction time difference between procedures of 12 minutes or more
- Loss or loosening of sutures before final assessment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 separate surgeries approximately 4 weeks apart
Participants undergo surgical extraction of an impacted mandibular third molar with wound closure using either triclosan-coated or non-coated polyglactin 910 sutures. This occurs twice with approximately 4 weeks between surgeries.
2 surgery visits (in-person)
Duration - Up to 1 week after each surgery
Participants attend follow-up visits on postoperative days 3, 5, and 7 after each surgery for clinical evaluations and laboratory testing of suture material to assess wound healing and bacterial adherence.
6 visits (in-person) across both surgery periods
Trial Site Locations
Total: 1 location
1
Specialized Dental Clinic, University of Medicine and Pharmacy at Ho Chi Minh City
Ho Chi Minh City, Vietnam
Actively Recruiting
Research Team
L
Le Khanh Huyen Nguyen
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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