Actively Recruiting
Wrist Extensor MEP Up-conditioning for Individuals With Incomplete Spinal Cord Injury
Led by Medical University of South Carolina · Updated on 2025-06-19
5
Participants Needed
1
Research Sites
246 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to examine the relationship between common clinical assessments and measurements of the function of brain-spinal cord-muscle connections, and to examine the effects of training a brain-spinal cord-muscle response in individuals with incomplete spinal cord injury. A transcranial magnetic stimulator (TMS) is used for examining brain-to-muscle pathways. This stimulator produces a magnetic field for a very short period of time and indirectly stimulates brain cells with little or no discomfort. The target muscle is the wrist extensor (extensor carpi radialis) muscle that bends the wrist back. It is hypothesized that training the wrist extensor muscle response to transcranial magnetic stimulation will increase the strength of the brain-to-muscle pathway, which will improve the ability to move the arm. It is hoped that the results of this training study will help in developing therapy strategies for individuals, promoting better understanding of clinical assessments, and understanding treatments that aim to improve function recovery in people with spinal cord injury (SCI). This study requires 30 visits, and each visit will last approximately 1.5 hours.
CONDITIONS
Official Title
Wrist Extensor MEP Up-conditioning for Individuals With Incomplete Spinal Cord Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of spinal cord injury at or above the C6 level
- Neurologically stable for more than 6 months after spinal cord injury
- Medical clearance to participate in the study
- Weak wrist extension in at least one arm
- Expectation that current medications will remain unchanged for at least 3 months, including stable use of anti-spasticity drugs if applicable
You will not qualify if you...
- Presence of motoneuron injury
- Medically unstable condition
- Cognitive impairment
- History of epileptic seizures
- Metal implants in the skull
- Implanted biomedical devices in or above the chest, such as pacemakers or cochlear implants
- No measurable motor evoked potential in the wrist extensor muscle
- Unable to produce any voluntary activity in the wrist extensor muscle
- Daily extensive use of functional electrical stimulation on the arm
- Pregnancy due to potential medical instability and posture changes
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
Research Team
B
Blair Dellenbach, MSOT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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