Actively Recruiting

Phase 2
Age: 18Years - 75Years
All Genders
NCT06351345

129 Xenon Imaging in Patients Treated With Sotatercept

Led by Bastiaan Driehuys · Updated on 2026-02-24

14

Participants Needed

1

Research Sites

223 weeks

Total Duration

On this page

Sponsors

B

Bastiaan Driehuys

Lead Sponsor

M

Merck Sharp & Dohme LLC

Collaborating Sponsor

AI-Summary

What this Trial Is About

Determine the ability of 129Xe MRI/MRS biomarker signatures to non-invasively monitor pulmonary vascular reverse remodeling induced by sotatercept in pulmonary arterial hypertension (PAH).

CONDITIONS

Official Title

129 Xenon Imaging in Patients Treated With Sotatercept

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Outpatients of either gender, Age 18-75
  • Diagnosis of precapillary pulmonary hypertension confirmed by right heart catheterization with mean pulmonary artery pressure 20 mmHg, pulmonary vascular resistance 25 5 WU, and pulmonary capillary wedge pressure 25 15 mmHg in Group 1 (PAH)
  • Willing to provide informed consent and follow study visit schedules
  • On a stable dose of background PAH therapy for more than 90 days before enrollment
  • Women of childbearing potential must have a negative urine pregnancy test before MRI
Not Eligible

You will not qualify if you...

  • Moderate to severe heart disease (left ventricular ejection fraction less than 45%, severe left ventricular hypertrophy, moderate to severe valvular disease)
  • Chronic thromboembolic disease
  • Pulmonary hypertension due to schistosomiasis
  • Active cancer
  • Sickle cell anemia
  • Prisoners and pregnant women are excluded
  • Conditions preventing MRI scanning such as metal in eye, claustrophobia, or inability to lie flat
  • Medical or psychological conditions that may pose risk or interfere with study participation

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Duke University Medical Center

Durham, North Carolina, United States, 27710

Actively Recruiting

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Research Team

C

Claudia Salazar

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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