Actively Recruiting
129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)
Led by Bastiaan Driehuys · Updated on 2026-02-24
20
Participants Needed
1
Research Sites
137 weeks
Total Duration
On this page
Sponsors
B
Bastiaan Driehuys
Lead Sponsor
A
American Heart Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall study objectives outlined in this study are to derive 129Xe MRI pulmonary vascular biomarker signatures that differentiate common subtypes of PAH and to determine the ability of 129Xe MRI to longitudinally monitor disease progression and response to therapy in PAH, with the aid of additional assessments, such as labs, echocardiography, and six-minute walk distance (6MWD).
CONDITIONS
Official Title
129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- WHO functional class 2 or 3
- Mean pulmonary artery pressure greater than 20 mmHg
- Pulmonary capillary wedge pressure of 15 mmHg or less
- Pulmonary vascular resistance greater than 2 Wood Units
- For Arm 1: Diagnosis of Idiopathic Pulmonary Arterial Hypertension with no other cause identified
- For Arm 2: Diagnosis of Pulmonary Arterial Hypertension associated with connective tissue disease
You will not qualify if you...
- Pulmonary hypertension other than Idiopathic PAH or PAH associated with connective tissue disease
- Any condition that prevents performing 129Xe MRI scans
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
C
Claudia Salazar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here