Actively Recruiting
129 Xenon MRI in Chronic Lung Disease
Led by Western University, Canada · Updated on 2024-06-13
100
Participants Needed
1
Research Sites
748 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Subjects aged 18-85 with lung disease will undergo hyperpolarized Xenon 129 (129-Xe) MRI and Pulmonary Function testing for the development of tools to evaluate the Apparent Diffusion Coefficient (ADC), ventilation defect percent (VDP) and pulmonary gas exchange measurements obtained by analysis of hyperpolarized 129-Xe MRI.
CONDITIONS
Official Title
129 Xenon MRI in Chronic Lung Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 85 years with diagnosed lung disease including asthma, emphysema, COPD, bronchiectasis, sarcoidosis, pulmonary fibrosis, alpha 1-anti-trypsin deficiency, or lymphangioleiomyomatosis (LAM)
- Willingness to participate and provide written informed consent
- Ability to hold breath for 16 seconds
- Judged to be in stable health based on medical history
- Able to perform reproducible pulmonary function testing with acceptable spirometry results
- Forced Expiratory Volume at one second (FEV1) greater than 25% predicted
- Forced Vital Capacity (FVC) greater than 25% predicted and greater than 0.5 liter
You will not qualify if you...
- Mentally or legally incapacitated individuals unable to provide informed consent or understand written material
- Daytime room air oxygen saturation less than or equal to 92% while lying down
- Unable to perform spirometry or plethysmography tests
- Unable to tolerate MRI due to body size or claustrophobia
- Pregnant or lactating individuals
- Physical or psychological conditions preventing MRI performance, such as severe claustrophobia
- Presence of MRI incompatible devices or non-removable metal in the body such as pacemakers, neurostimulators, insulin pumps, aneurysm clips, bioprosthesis, metallic fragments, shunts, surgical staples, or ear implants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
London, Ontario, Canada, N6A 5B7
Actively Recruiting
Research Team
G
Grace E Parraga, PhD
CONTACT
A
Angela P Wilson, RRT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here