Actively Recruiting
Zanamivir Treatment of Vascular Permeability in Dengue (ZAP-DENGUE)
Led by George Washington University · Updated on 2025-07-28
74
Participants Needed
2
Research Sites
132 weeks
Total Duration
On this page
Sponsors
G
George Washington University
Lead Sponsor
N
Naval Medical Research Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
ZAP-DENGUE is a pilot randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of five days of intravenous zanamivir treatment to treat vascular permeability syndrome which is the main cause of death in dengue fever.
CONDITIONS
Official Title
Zanamivir Treatment of Vascular Permeability in Dengue (ZAP-DENGUE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form provided
- Willingness to comply with all study procedures and be available for the study duration
- Male or female aged over 7 years
- Willingness to receive intravenous medication and follow the medication schedule
- Diagnosis of dengue confirmed by dengue NS1 rapid test
- Self-reported fever above 38 degrees Celsius within the last 3 days
- Dengue with warning signs as per 2009 WHO criteria or severe dengue including symptoms like abdominal pain, persistent vomiting, fluid accumulation, mucosal bleeding, lethargy, restlessness, liver enlargement over 2 cm, increased hematocrit, thrombocytopenia, or severe plasma leakage leading to shock or respiratory distress
- Enrollment in Colombian Public Health Insurance (EPS or SGSSS)
You will not qualify if you...
- Pregnancy or breastfeeding
- Children under state care
- Patients unlikely to survive more than 48 hours
- Unstable heart disease or arrhythmia at baseline
- History of significant heart disease
- Treatment with another investigational drug or intervention within the past month
- Encephalitis or inability to provide consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Cien Salud IPS SAS
Barranquilla, Atlántico, Colombia, 080020
Active, Not Recruiting
2
Clinica de la Costa SAS
Barranquilla, Colombia, Colombia, 080020
Actively Recruiting
Research Team
A
Aileen Y Chang, MD
CONTACT
A
Alfonso Sucerquia, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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