Actively Recruiting
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
Led by Exelixis · Updated on 2026-04-17
440
Participants Needed
80
Research Sites
201 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary purpose of this study is to assess the effectiveness of zanzalintinib compared to everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors.
CONDITIONS
Official Title
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed, locally advanced/unresectable or metastatic, well-differentiated Grade 1, 2, or 3 neuroendocrine tumors of pancreatic or extra-pancreatic origin.
- Allowed prior lines of therapy based on tumor site and functional status.
- Radiographic disease progression per RECIST 1.1 within 12 months before randomization.
- Measurable disease according to RECIST 1.1.
- Archival tumor tissue available, or fresh biopsy if safely obtainable.
You will not qualify if you...
- Histologically confirmed neuroendocrine carcinomas including small cell lung cancer, medullary thyroid cancer, pheochromocytoma, paraganglioma, Merkel cell carcinoma, and mixed neuroendocrine non-neuroendocrine neoplasm.
- Prior treatment with VEGFR-targeting tyrosine kinase inhibitor or mTOR inhibitor.
- Systemic chemotherapy or liver-directed/ablative therapy within 4 weeks before randomization.
- Systemic radionuclide therapy within 6 weeks before randomization.
- Radiation therapy for bone metastases within 2 weeks or other radiation therapy within 4 weeks before randomization.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 80 locations
1
Exelixis Clinical Site #43
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
Exelixis Clinical Site #36
Phoenix, Arizona, United States, 85054
Actively Recruiting
3
Exelixis Clinical Site #42
Tucson, Arizona, United States, 85724
Actively Recruiting
4
Exelixis Clinical Site #18
Beverly Hills, California, United States, 90211
Actively Recruiting
5
Exelixis Clinical Site #16
Los Angeles, California, United States, 90033
Actively Recruiting
6
Exelixis Clinical Site #54
Palo Alto, California, United States, 94305
Actively Recruiting
7
Exelixis Clinical Site #12
Santa Monica, California, United States, 90404
Actively Recruiting
8
Exelixis Clinical Site #29
Vallejo, California, United States, 94589
Actively Recruiting
9
Exelixis Clinical Site #19
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
10
Exelixis Clinical Site #35
Jacksonville, Florida, United States, 32224
Actively Recruiting
11
Exelixis Clinical Site #11
Tampa, Florida, United States, 33612
Actively Recruiting
12
Exelixis Clinical Site #9
Lexington, Kentucky, United States, 40536
Actively Recruiting
13
Exelixis Clinical Site #23
Metairie, Louisiana, United States, 70006
Actively Recruiting
14
Exelixis Clinical Site #8
Boston, Massachusetts, United States, 02215
Actively Recruiting
15
Exelixis Clinical Site #47
Detroit, Michigan, United States, 48202
Actively Recruiting
16
Exelixis Clinical Site #1
Grand Rapids, Michigan, United States, 49546
Actively Recruiting
17
Exelixis Clinical Site #38
Rochester, Minnesota, United States, 55905
Actively Recruiting
18
Exelixis Clinical Site #5
St Louis, Missouri, United States, 63110
Actively Recruiting
19
Exelixis Clinical Site #25
Omaha, Nebraska, United States, 68198
Actively Recruiting
20
Exelixis Clinical Site #14
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
21
Exelixis Clinical Site #59
Buffalo, New York, United States, 14263
Actively Recruiting
22
Exelixis Clinical Site #7
New York, New York, United States, 10029
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23
Exelixis Clinical Site #53
Rochester, New York, United States, 14642
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24
Exelixis Clinical Site #17
Chapel Hill, North Carolina, United States, 27599
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25
Exelixis Clinical Site #6
Durham, North Carolina, United States, 27710
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26
Exelixis Clinical Site #57
Fargo, North Dakota, United States, 58102
Actively Recruiting
27
Exelixis Clinical Site #39
Cleveland, Ohio, United States, 44106
Actively Recruiting
28
Exelixis Clinical Site #28
Columbus, Ohio, United States, 43221
Actively Recruiting
29
Exelixis Clinical Site #27
Portland, Oregon, United States, 97210
Actively Recruiting
30
Exelixis Clinical Site #20
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
31
Exelixis Clinical Site #21
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
32
Exelixis Clinical Site #24
Knoxville, Tennessee, United States, 37920
Actively Recruiting
33
Exelixis Clinical Site #65
Nashville, Tennessee, United States, 37232
Actively Recruiting
34
Exelixis Clinical Site #10
Dallas, Texas, United States, 75264
Actively Recruiting
35
Exelixis Clinical Site #15
Salt Lake City, Utah, United States, 84112
Actively Recruiting
36
Exelixis Clinical Site #3
Charlottesville, Virginia, United States, 22903
Actively Recruiting
37
Exelixis Clinical Site #13
Fairfax, Virginia, United States, 22031
Actively Recruiting
38
Exelixis Clinical Site #34
Seattle, Washington, United States, 98109
Actively Recruiting
39
Exelixis Clinical Site #31
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
40
Exelixis Clinical Site #40
Saint Leonards, New South Wales, Australia, 2065
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41
Exelixis Clinical Site #67
Woodville South, South Australia, Australia, 5011
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42
Exelixis Clinical Site #51
Clayton, Victoria, Australia, 3168
Actively Recruiting
43
Exelixis Clinical Site #68
Clayton, Victoria, Australia, 3168
Actively Recruiting
44
Exelixis Clinical Site #55
Herston, Australia, 4029
Actively Recruiting
45
Exelixis Clinical Site #48
Graz, Austria, 8036
Actively Recruiting
46
Exelixis Clinical Site #61
Ottawa, Canada, K1H8L6
Actively Recruiting
47
Exelixis Clinical Site #49
Toronto, Canada, M4N3M5
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48
Exelixis Clinical Site #63
Hong Kong, China
Actively Recruiting
49
Exelixis Clinical Site 58
Berlin, Germany, 13125
Actively Recruiting
50
Exelixis Clinical Site #52
Tübingen, Germany, 72076
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51
Exelixis Clinical Site #75
Würzburg, Germany, 97080
Actively Recruiting
52
Exelixis Clinical Site #77
China, Hong Kong
Actively Recruiting
53
Exelixis Clinical Site #78
Naples, Naples, Italy, 80131
Actively Recruiting
54
Exelixis Clinical Site #70
Roma, Italy, 00185
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55
Exelixis Clinical Site #69
Warsaw, Masovian Voivodeship, Poland, 02-034
Actively Recruiting
56
Exelixis Clinical Site #45
Katowice, Poland, 40-514
Actively Recruiting
57
Exelixis Clinical Site #37
Warsaw, Poland, 53-673
Actively Recruiting
58
Exelixis Clinical Site #72
Gliwice, Ślaskie, Poland, 44-102
Actively Recruiting
59
Exelixis Clinical Site #2
San Juan, Puerto Rico, 00909
Actively Recruiting
60
Exelixis Clinical Site # 4
San Juan, Puerto Rico, 00927
Withdrawn
61
Exelixis Clinical Site #30
Seoul, South Korea, 02841
Actively Recruiting
62
Exelixis Clinical Site #46
Seoul, South Korea, 03080
Actively Recruiting
63
Exelixis Clinical Site #32
Seoul, South Korea, 03722
Actively Recruiting
64
Exelixis Clinical Site #41
Seoul, South Korea, 05505
Actively Recruiting
65
Exelixis Clinical Site #26
Seoul, South Korea, 06351
Actively Recruiting
66
Exelixis Clinical Site #74
Santiago de Compostela, A Coruña, Spain, 15706
Actively Recruiting
67
Exelixis Clinical Site #80
Oviedo, Principality of Asturias, Spain, 33011
Actively Recruiting
68
Exelixis Clinical Site #76
Barcelona, Spain, 08029
Actively Recruiting
69
Exelixis Clinical Site #56
Madrid, Spain, 28034
Actively Recruiting
70
Exelixis Clinical Site #73
Madrid, Spain, 28041
Actively Recruiting
71
Exelixis Clinical Site #44
Madrid, Spain, 28046
Actively Recruiting
72
Exelixis Clinical Site #66
Murcia, Spain, 30008
Actively Recruiting
73
Exelixis Clinical Site #60
Santander, Spain, 39008
Actively Recruiting
74
Exelixis Clinical Site #62
Seville, Spain, 41013
Actively Recruiting
75
Exelixis Clinical Site #64
Valencia, Spain, 46026
Actively Recruiting
76
Exelixis Clinical Site #79
Zaragoza, Spain, 50009
Actively Recruiting
77
Exelixis Clinical Site #22
London, England, United Kingdom, SE5 9RS
Actively Recruiting
78
Exelixis Clinical Site #71
Oxford, England, United Kingdom, OX3 7LE
Actively Recruiting
79
Exelixis Clinical Site #50
Liverpool, United Kingdom, L7 8YA
Actively Recruiting
80
Exelixis Clinical Site #33
Sheffield, United Kingdom, S10 2SJ
Actively Recruiting
Research Team
E
Exelixis Clinical Trials
CONTACT
B
Backup or International
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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