Actively Recruiting
Zinc as an Adjunctive Therapy for Cervical Dystonia
Led by University of Florida · Updated on 2026-03-09
20
Participants Needed
1
Research Sites
44 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate if supplemental zinc can prolong the duration of benefit of botulinum toxin injections in cervical dystonia patients receiving care at the University of Florida. The main aims are: 1. To evaluate the efficacy of zinc citrate supplementation in prolonging the duration of symptom relief provided by botulinum toxin type A (Botox) injections in cervical dystonia patients. 2. To assess the safety and tolerability of zinc supplementation in this patient population. 3. To analyze the potential influence of zinc supplementation on the quality of life and functional outcomes in cervical dystonia patients receiving Botox. Researchers will compare zinc citrate to a placebo (a look-alike substance that contains no active drug) to see if zinc works to extend the effects of Botox. Participants will: Take zinc citrate or a placebo every day for 3 months, then cross over to the alternative treatment for another 3 months. Visit the clinic every 3 months for Botox injections, check ups and surveys.
CONDITIONS
Official Title
Zinc as an Adjunctive Therapy for Cervical Dystonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18-65 years
- Diagnosed with cervical dystonia
- Receiving regular BoNT type A (Botox) injections for at least one year
You will not qualify if you...
- Known allergy or intolerance to zinc
- Significant comorbidities or concurrent medications that could interfere with study outcomes
- Pregnant or breastfeeding women
- Already taking a zinc supplement exceeding 40 mg elemental zinc per day when combined with study supplement
AI-Screening
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Trial Site Locations
Total: 1 location
1
Norman Fixel Institute for Neurological Diseases
Gainesville, Florida, United States, 32608
Actively Recruiting
Research Team
J
Julie Segura, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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