Actively Recruiting
Zoledronate to Prevent Bone Health Complications in Pediatric Hematopoietic Stem Cell Transplant Survivors
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2026-01-29
20
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this pilot study is to investigate the safety and preliminarily assess efficacy of early intervention with zoledronate in high risk pediatric hematopoietic stem cell transplantation (HSCT) patients to prevent the development of bone disease and fractures and reduce potential pain and suffering.
CONDITIONS
Official Title
Zoledronate to Prevent Bone Health Complications in Pediatric Hematopoietic Stem Cell Transplant Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 5 to 18 years preparing for HSCT with a height-for-age corrected DXA Z-score below -2.0 and admitted to a CCHMC inpatient unit
- Patients aged 5 to 18 years recovering from HSCT who have developed new acute or chronic GVHD and are admitted to a CCHMC inpatient unit
You will not qualify if you...
- Age less than 5 years or greater than 18 years
- Patients with Fanconi anemia or other radiation-sensitive syndromes with increased malignancy risk
- History of prior bisphosphonate use
- Low 25-OH vitamin D levels (less than 20 ng/mL)
- Active febrile illness
- Uncontrolled infection
- Elevated creatinine at enrollment, history of renal failure, or low glomerular filtration rate (GFR 90)
- Active bone disease including abnormal PTH levels, active fractures or healing, or primary bone development or metabolism disorders
- Women who are pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
Research Team
J
Jessi Anderson
CONTACT
B
Brady Landon
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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