Discussing clinical trial participation with patients requires clarity, empathy, and ethical responsibility. As a healthcare provider, your recommendation carries significant weight in how patients perceive research. A well-informed, non-coercive conversation can help them explore opportunities that align with their care goals.

How to Initiate the Conversation

• Begin with relevance: Explain why you’re suggesting a clinical trial, e.g., “There’s a research opportunity studying new treatments for your condition.”
• Use plain language: Avoid technical jargon. Clearly describe what the trial is studying, how it differs from routine care, and what it may involve.
• Normalize participation: Let patients know that research is a voluntary and respected part of healthcare, and many others explore these options.
• Clarify your role: Emphasize that your support continues whether or not they choose to participate.

What to Cover in the Discussion

• What the study is about
• What participation may involve (e.g., visits, procedures, risks, time commitment)
• Their rights (e.g., informed consent, right to withdraw)
• What is not guaranteed (e.g., benefit or access to treatment post-trial)
• How privacy will be protected

Key Do’s and Don’ts

Do	Don’t
Explain risks and benefits clearly	Promise outcomes or benefits
Encourage questions	Pressure the patient to decide
Offer written information	Skip informed consent basics

Key Note: Always give patients time to think, discuss with family, or speak with the research team. Their decision should be voluntary and fully informed. If you’re unsure how to explain a specific trial, DecenTrialz provides ready-made explainer materials to support your conversations.