Inclusion Criteria

Concurrent Medication:

Allowed:

• Acetaminophen.

Patients must have:

-

Clinically documented AIDS or AIDS-related complex (ARC) defined as CDC group IVA or history of any of the findings that define CDC group IV subgroup C-2:

• oral candidiasis, oral hairy leukoplakia, multidermatomal herpes zoster, recurrent nontyphoidal Salmonella bacteremia, or nocardiosis.

Prior Medication:

Allowed:

• Acetaminophen.

Exclusion Criteria

Concurrent Treatment:

Excluded:

• Intramuscular injections.

Patients will be excluded from the study for the following reasons:

• Acute illness requiring hospitalization or antiviral drug therapy for treatment.
• Volunteers who have taken any antiviral medications, anticoagulants, antiplatelet medications, or any nonsteroidal anti-inflammatory drugs, except acetaminophen, within 2 weeks of study entry, or those who anticipate the need for such medication during the study.
• Positive stool guaiac at screening.
• Disorders of coagulation or any known contraindication to anticoagulation, including but not limited to gastrointestinal or other serious bleeding, major trauma or surgery within the past 2 months, stroke or suspicion of central nervous system (CNS) bleeding, Kaposi sarcoma (with or without proven gastrointestinal involvement), and any known CNS lesions that might be prone to bleed.
• Allergy to dextran sulfate or heparin.
• Acute or asymptomatic HIV infection.

Prior Medication:

Excluded:

• Antiviral medications.
• Anticoagulants.
• Antiplatelet medications.
• Any nonsteroidal anti-inflammatory drugs (except acetaminophen).

Prior Treatment:

Excluded:

• Hospitalization for acute illness.

Patients may not have any of the following diseases or symptoms:

• Allergy to dextran sulfate or heparin.
• Acute or asymptomatic HIV infection.
• Acute illness requiring hospitalization.
• Chronic anemia requiring transfusion within the past month.
• Disorders of coagulation or any known contraindication to anticoagulation, including but not limited to gastrointestinal or other serious bleeding, major trauma or surgery within the past 2 months, stroke or suspicion of central nervous system (CNS) bleeding, Kaposi's sarcoma, and any known CNS lesions which might be prone to bleed.