What is this study trying to find out about HIV and overdose prevention?

This study is evaluating a peer-driven intervention aimed at reducing HIV, hepatitis C virus (HCV) transmission, and overdose risk behaviors among people who inject drugs. It is exploring how peer education and providing materials in injection settings can influence safer practices. The research is sponsored by the Johns Hopkins Bloomberg School of Public Health.

Who may be eligible for this HIV prevention clinical trial?

Adults aged 18 or older who currently use drugs, including opioids, and have used them in the past two weeks may be eligible. The study accepts all genders but excludes individuals with mental or physical health issues that would make participation difficult. Please review eligibility criteria for more details.

Is there any cost to participate in this HIV prevention clinical trial?

Study-related care, including the behavioral training and all trial visits, is provided at no cost. Personal travel or other expenses may vary and are not guaranteed to be covered.

Actively Recruiting

Phase Not Applicable

Age: 18Years +

All Genders

Healthy Volunteers

ID05320835

Pilot Study of a Peer-Driven Injection Setting Intervention to Prevent HIV, Hepatitis C, and Overdose Among People Who Inject Drugs in Baltimore

Led by Johns Hopkins Bloomberg School of Public Health · Updated on 2026-05-22

285

Participants Needed

Research Sites

25 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating a pilot intervention aimed at reducing HIV and hepatitis C virus HCV transmission, as well as overdose risk behaviors, among people who inject drugs PWID. The study uses a peer-driven approach targeting semi-public injection settings SPIS to promote safer practices. This intervention is grounded in social influence, social network, and social cognitive theories, focusing on improving communication and peer education to change social norms around risk behaviors. Participants will be randomly assigned to one of two groups one receiving behavioral training with six sessions that include peer education and stocking of SPIS with risk reduction materials, and the other receiving an attention control standard care. The intervention seeks to increase conversations about prevention and the availability of naloxone and other risk reduction materials in injection settings to reduce sharing of injection equipment and overdose risks. During the study, 120 index PWID participants will be selected based on their use of SPIS. Their involvement includes participation in the training sessions or control activities, with researchers monitoring overdose prevention and HIVHCV prevention outcomes over six months. Assessments will include measures of overdose behaviors and related risk factors to evaluate how well the intervention influences these outcomes over time.

CONDITIONS

Brief Title

A Setting Focus Overdose Prevention Intervention

Who Can Participate

Age: 18Years +

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Current drug user with opioid use in the prior two weeks
Age 18 years or older

You will not qualify if you...

Any mental or physical health impairment that impedes ability to participate in the study or training sessions
Inability to provide informed consent or participate fully in study activities
Any condition that would make participation unsafe or unfeasible as determined by investigators (if applicable based on health status assessment in screening process, though not explicitly stated in source, this is implied by impairment criteria but is not added as separate bullet here to adhere strictly to source text rules). Note: Only the explicit exclusion about mental or physical health impairment is included per source instructions; no additional criteria are invented.

Research Team

Carl Latkin, PhD

Lauren Dayton, PhD

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