Inclusion Criteria

Concurrent Medication:

Allowed:

• Nystatin or clotrimazole for suppression of oral thrush.
• Aerosolized pentamidine for Pneumocystis prophylaxis in Group A patients.
• Trimethoprim / sulfamethoxazole for Pneumocystis prophylaxis in patients who are hematologically stable on trimethoprim / sulfamethoxazole.

Patients must have:

• Group A: AIDS and symptoms defined in disease status.
• Group B: AIDS related complex (ARC) and symptoms defined in disease status.

Exclusion Criteria

Co-existing Condition:

Patients with the following disease or conditions are excluded:

• Malignancies other than Kaposi's sarcoma.
• AIDS dementia.
• Opportunistic infections requiring ongoing therapy except oral thrush suppression with nystatin or clotrimazole or Pneumocystis prophylaxis in Group A patients.
• Significant organ system dysfunction including:
• Granulocytopenia with a granulocyte count < 1000 cells/mm3.
• Thrombocytopenia - < 75000 platelets/mm3.
• Anemia with a hemoglobin < 9.5 g/dl.
• Renal dysfunction - creatinine > 2 mg/dl.
• Hepatic dysfunction with enzymes or bilirubin > 3 x upper limit of normal.

Patients with the following are excluded:

• Preexisting antibodies to rCD4.
• Malignancies other than Kaposi's sarcoma.
• AIDS-dementia complex.
• Opportunistic infections requiring ongoing therapy.
• Significant organ system dysfunction.
• Inability to sign voluntarily the consent form.

Prior Medication:

Excluded:

• Recombinant soluble CD4 protein (rCD4).
• Excluded within 30 days of study entry:
• Immunomodulatory therapy or agent with anti-HIV activity.
• Chemotherapy.

Prior Treatment:

Excluded within 30 days of study entry:

• Radiotherapy.

Active illicit drug use or alcohol abuse at time of entry.