Inclusion Criteria

Subjects must have:

• Normal history and physical exam.
• Negative ELISA for HIV.
• Normal cell-mediated immune responses using Merieux skin test.
• Normal urinalysis.

Exclusion Criteria

Co-existing Condition:

Subjects with the following conditions are excluded:

• Evidence of psychological or psychiatric problems that may lead to noncompliance with study requirements.
• Positive syphilis serology. If serology is documented as a false positive or is due to a remote (> 6 months) treated infection, subject is eligible.
• Circulating hepatitis B surface antigen.

Subjects with the following prior conditions are excluded:

• History of immunodeficiency, chronic illness, autoimmune disease, or use of immunosuppressive medications.
• History of anaphylaxis or other adverse reactions to vaccines.

Prior Medication:

Excluded:

• Prior HIV vaccines.
• Immunoglobulins or vaccines within the past 3 months.
• Experimental agents within the past 30 days.

Prior Treatment:

Excluded:

• Blood transfusions or cryoprecipitates within the past 3 months.

Identifiable high-risk behavior for HIV infection, including:

• Any history of intravenous (IV) drug use within the past year.
• Syphilis, gonorrhea, or any other sexually transmitted diseases (including chlamydia or pelvic inflammatory disease) in the past 6 months.
• More than two sexual partners, or sexual contact with a high-risk partner, in the past 6 months.