Completed
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2021-11-04
700
Participants Needed
44
Research Sites
N/A
Total Duration
To compare the efficacy and safety of dapsone versus atovaquone in preventing or delaying the onset of histologically proven or probable Pneumocystis carinii pneumonia in HIV-infected patients with CD4 counts \<= 200 cells/mm3 or \<= 15 percent of the total lymphocyte count who are intolerant to trimethoprim and/or sulfonamides. Trimethoprim/sulfamethoxazole (TMP/SMX), which is effective for secondary PCP prophylaxis, is associated with allergic manifestations and side effects that limit its use. Patients who are intolerant of TMP/SMX require an effective alternative. Dapsone and atovaquone have both shown promise as PCP prophylactic agents.
CONDITIONS
A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides
You may qualify if you...
Inclusion Criteria
Concurrent Medication: Strongly recommended:
Patients must have:
NOTE:
Prior Medication:
Allowed:
Exclusion Criteria
Co-existing Condition:
Patients with the following symptoms or conditions are excluded:
Concurrent Medication:
Excluded:
Patients with the following prior conditions are excluded:
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Total: 44 locations
1
Alabama Therapeutics CRS
Birmingham, Alabama, United States, 35294
Status Unknown
2
USC CRS
Los Angeles, California, United States, 900331079
Status Unknown
3
Stanford CRS
Palo Alto, California, United States, 943055107
Status Unknown
4
Ucsd, Avrc Crs
San Diego, California, United States, 921036325
Status Unknown
5
Ucsf Aids Crs
San Francisco, California, United States, 941102859
Status Unknown
6
Santa Clara Valley Med. Ctr.
San Jose, California, United States, 951282699
Status Unknown
7
San Mateo County AIDS Program
San Mateo, California, United States
Status Unknown
8
Harbor-UCLA Med. Ctr. CRS
Torrance, California, United States, 90502
Status Unknown
9
University of Colorado Hospital CRS
Aurora, Colorado, United States, 80262
Status Unknown
10
Howard University Hosp., Div. of Infectious Diseases, ACTU
Washington D.C., District of Columbia, United States, 20059
Status Unknown
11
Univ. of Miami AIDS CRS
Miami, Florida, United States, 331361013
Status Unknown
12
Emory Univ. Hemophilia Program Office
Atlanta, Georgia, United States, 303652225
Status Unknown
13
Queens Med. Ctr.
Honolulu, Hawaii, United States, 96816
Status Unknown
14
Univ. of Hawaii at Manoa, Leahi Hosp.
Honolulu, Hawaii, United States, 96816
Status Unknown
15
Northwestern University CRS
Chicago, Illinois, United States, 60611
Status Unknown
16
Cook County Hosp. CORE Ctr.
Chicago, Illinois, United States, 60612
Status Unknown
17
Rush Univ. Med. Ctr. ACTG CRS
Chicago, Illinois, United States, 60612
Status Unknown
18
Weiss Memorial Hosp.
Chicago, Illinois, United States, 60640
Status Unknown
19
Indiana Univ. School of Medicine, Infectious Disease Research Clinic
Indianapolis, Indiana, United States, 462025250
Status Unknown
20
Univ. of Iowa Healthcare, Div. of Infectious Diseases
Iowa City, Iowa, United States, 52242
Status Unknown
21
Johns Hopkins Adult AIDS CRS
Baltimore, Maryland, United States, 21287
Status Unknown
22
Bmc Actg Crs
Boston, Massachusetts, United States, 02118
Status Unknown
23
Beth Israel Deaconess - East Campus A0102 CRS
Boston, Massachusetts, United States, 02215
Status Unknown
24
Massachusetts General Hospital ACTG CRS
Boston, Massachusetts, United States
Status Unknown
25
Hennepin County Med. Ctr., Div. of Infectious Diseases
Minneapolis, Minnesota, United States, 55415
Status Unknown
26
University of Minnesota, ACTU
Minneapolis, Minnesota, United States, 55455
Status Unknown
27
St. Louis ConnectCare, Infectious Diseases Clinic
St Louis, Missouri, United States
Status Unknown
28
Washington U CRS
St Louis, Missouri, United States
Status Unknown
29
Univ. of Nebraska Med. Ctr., Durham Outpatient Ctr.
Omaha, Nebraska, United States
Status Unknown
30
SUNY - Buffalo, Erie County Medical Ctr.
Buffalo, New York, United States, 13210
Status Unknown
31
Beth Israel Med. Ctr. (Mt. Sinai)
New York, New York, United States
Status Unknown
32
NY Univ. HIV/AIDS CRS
New York, New York, United States
Status Unknown
33
Univ. of Rochester ACTG CRS
Rochester, New York, United States, 14642
Status Unknown
34
Unc Aids Crs
Chapel Hill, North Carolina, United States
Status Unknown
35
Carolinas HealthCare System, Carolinas Med. Ctr.
Charlotte, North Carolina, United States, 28203
Status Unknown
36
Regional Center for Infectious Disease, Wendover Medical Center CRS
Greensboro, North Carolina, United States, 27401
Status Unknown
37
Wake County Health and Human Services CRS
Raleigh, North Carolina, United States, 27610
Status Unknown
38
Univ. of Cincinnati CRS
Cincinnati, Ohio, United States
Status Unknown
39
Case CRS
Cleveland, Ohio, United States, 44106
Status Unknown
40
MetroHealth CRS
Cleveland, Ohio, United States
Status Unknown
41
The Ohio State Univ. AIDS CRS
Columbus, Ohio, United States, 432101228
Status Unknown
42
Hosp. of the Univ. of Pennsylvania CRS
Philadelphia, Pennsylvania, United States, 19104
Status Unknown
43
University of Washington AIDS CRS
Seattle, Washington, United States, 981224304
Status Unknown
44
Mbeya Med. Research Program, Mbeya Referral Hosp. CRS
Mbeya, Tanzania
Status Unknown
Study Type
INTERVENTIONAL
Masking
N/A
Allocation
N/A
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
0
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W M El-Sadr, R L Murphy, T M Yurik...
https://pubmed.ncbi.nlm.nih.gov/9862944