Inclusion Criteria

Concurrent Medication:

Recommended:

• PCP prophylaxis.

Allowed:

• Acetaminophen for no more than 72 hours.
• Immunoglobulin.
• Corticosteroids.
• Erythropoietin.
• G-CSF and GM-CSF.
• Ethionamide or isoniazid for TB if no alternative available.
• Immunizations according to current recommendations.

Patients must have:

• HIV infection.
• Immunologic abnormality or clinical symptoms as detailed in the Disease Status field.
• No active AIDS-defining opportunistic infection or malignancy, no progressive encephalopathy attributable to HIV and no chronic persistent diarrhea.
• Consent of parent or guardian.

PER AMENDMENT 7/2/96:

• At least 2 of the 5 children in the older half of each cohort must have an ICD p24 antigen concentration >= 70 pg/ml at screening.

Prior Medication:

Allowed:

• Up to 6 weeks of prior immunomodulator therapy.
• Maternal immunomodulator or antiretroviral therapy, including during pregnancy.
• Prior corticosteroids or intravenous immunoglobulin.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

• Current grade 3 or worse neuropathy/lower motor neuropathy.
• Clinical or laboratory grade 3 or worse toxicities.
• Active serious bacterial infection.

Concurrent Medication:

Excluded:

• Chemotherapy for active malignancy.
• Antiretrovirals other than study drugs.
• Immunomodulators unless specifically allowed.

Patients with the following prior condition are excluded:

• History of grade 3 or worse neuropathy/lower motor neuropathy.

Prior Medication:

Excluded:

• Prior ddI or oral ribavirin.
• Aerosolized ribavirin within 6 weeks prior to study entry.
• Antiretroviral or immunomodulator therapy (other than corticosteroids or IVIG) within 1 week prior to blood draws for study entry.

Ongoing drug or alcohol abuse.