Inclusion Criteria

You may be eligible for this study if you:

• Are HIV-positive and have an HIV RNA count below 100,000 copies/ml within 30 days prior to study entry.
• Are taking methadone.
• Are at least 18 years old.
• Are within 40% of your ideal body weight and weigh at least 99 lbs.

Exclusion Criteria

You will not be eligible for this study if you:

• Are allergic to or are unable to take RTV or SQV.
• Have a history of treatment failure with indinavir, RTV, or SQV.
• Have a history of certain illnesses that might prevent you from completing the study.
• Have severe diarrhea or other stomach problems.
• Have taken any PI within 4 weeks prior to study entry.
• Would be unable to complete the study due to alcohol or drug abuse.
• Are co-enrolled in other protocols that have you taking medications that are prohibited in this study.
• Are taking PIs other than RTV or SQV.
• Are receiving certain therapies or are taking certain medications, including experimental drugs.
• Have an active opportunistic (AIDS-related) infection or disease that requires medication within 14 days prior to study entry.
• Are pregnant or breast-feeding.