Completed
Effects of Prophylaxis for Disseminated Mycobacterium Avium Complex (MAC) Disease With Azithromycin Versus Deferred Prophylaxis on Carriage of Antibiotic-Resistant Streptococcus Pneumoniae: A Substudy of the CR-MAC Protocol (CPCRA 048)
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2021-10-29
326
Participants Needed
15
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Some people who have taken azithromycin to prevent MAC (Mycobacterium avium Complex, a bacterial infection common in HIV-infected persons) have been found to carry antibiotic-resistant bacteria (germs that grow despite the presence of drugs used to kill them). The purpose of this study is to see if people who take azithromycin carry more antibiotic-resistant bacteria than people who have chosen to delay MAC preventive therapy. When bacteria like Streptococcus (a type of bacteria that causes pneumonia and meningitis) are frequently exposed to antibiotics, the bacteria can become resistant to the drugs. MAC preventive therapy uses antibiotics, but this can make it difficult to treat other infections caused by bacteria that have become resistant in HIV-infected persons. If MAC preventive therapy is delayed, Streptococcus in the body may be less likely to develop resistance. Therefore, if the patient does get a Streptococcus infection, it will be easier to treat because it is not resistant to the antibiotics.
CONDITIONS
Official Title
Effects of MAC Preventive Therapy on Disease-Causing Bacteria in HIV-Infected Patients: A Substudy of CPCRA 048
Who Can Participate
Eligibility Criteria
You may qualify if you...
Inclusion Criteria
You may be eligible for this study if you:
- Are enrolled in CPCRA 048.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 15 locations
1
Community Consortium / UCSF
San Francisco, California, United States, 94110
Status Unknown
2
Denver CPCRA / Denver Public Hlth
Denver, Colorado, United States, 80204
Status Unknown
3
Washington Reg AIDS Prog / Dept of Infect Dis
Washington D.C., District of Columbia, United States, 20422
Status Unknown
4
AIDS Research Consortium of Atlanta
Atlanta, Georgia, United States, 30308
Status Unknown
5
AIDS Research Alliance - Chicago
Chicago, Illinois, United States, 60657
Status Unknown
6
Louisiana Comm AIDS Rsch Prog / Tulane Univ Med
New Orleans, Louisiana, United States, 70112
Status Unknown
7
Wayne State Univ - WSU/DMC / Univ Hlth Ctr
Detroit, Michigan, United States, 48201
Status Unknown
8
Henry Ford Hosp
Detroit, Michigan, United States, 48202
Status Unknown
9
Southern New Jersey AIDS Cln Trials / Dept of Med
Camden, New Jersey, United States, 08103
Status Unknown
10
North Jersey Community Research Initiative
Newark, New Jersey, United States, 07103
Status Unknown
11
Partners in Research / New Mexico
Albuquerque, New Mexico, United States, 87131
Status Unknown
12
Harlem AIDS Treatment Grp / Harlem Hosp Ctr
New York, New York, United States, 10037
Status Unknown
13
The Research and Education Group
Portland, Oregon, United States, 97210
Status Unknown
14
Philadelphia FIGHT
Philadelphia, Pennsylvania, United States, 19107
Status Unknown
15
Richmond AIDS Consortium / Div of Infect Diseases
Richmond, Virginia, United States, 23298
Status Unknown
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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