A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.
Y Miki, J Swensen, D Shattuck-Eidens...
https://pubmed.ncbi.nlm.nih.gov/7545954Completed
All Genders
ID00001496
Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer
Led by National Cancer Institute (NCI) · Updated on 2008-03-04
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Women who are at high risk for breast cancer, either because of linkage to high risk breast and ovarian cancer families, or because of a carcinoma in the opposite breast, will be studied. Women will have a physical examination and mammography to ensure that no breast abnormalities are present. Eligible women will undergo biopsy of the breast to obtain normal breast tissue. Short-term cell cultures will be established from this tissue and early passages of the short-term cell lines will be stored. A bank of high risk normal mammary epithelial cells will be established. To further characterize the mammary epithelial cells in this population of women, cell cultures will subsequently be analyzed for their growth and metabolic properties, sensitivity to chemopreventive agents, steroid receptor characteristics, oncogene expression and regulation, and genetic changes.
CONDITIONS
Official Title
Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer
Who Can Participate
All Genders
Eligibility Criteria
You may qualify if you...
Women at high risk for breast cancer, either because they are a member of a high risk breast or ovarian cancer family, or because of a carcinoma of the opposite breast.
Normal mammogram within past 3 months.
No suspicious breast or axillary lesions on physical examination.
No major cardiopulmonary, hepatic or renal disorders.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Cancer Institute (NCI)
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Cellular characterization and retroviral transduction of short-term breast cancer cells.
M K Sgagias, D C Gagneton, S A Rosenberg...
https://pubmed.ncbi.nlm.nih.gov/7647960Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.
R Wooster, S L Neuhausen, J Mangion...
https://pubmed.ncbi.nlm.nih.gov/8091231