Status:
COMPLETED
A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With Peripheral Blood Progenitor Cell Support, and Intensification With Paclitaxel and Doxorubicin for Patients With High-Risk Breast Cancer
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Breast Cancer
Breast Neoplasms
Eligibility:
All Genders
Phase:
PHASE2
Brief Summary
Stage III patients may begin therapy prior to or following surgery. Patients with undrainable significant third space fluid collection (e.g., pleural effusions, ascites) are entered directly on Consol...
Detailed Description
This pilot trial will examine the feasibility of administering induction high-dose therapy with antimetabolites, followed with consolidation using high-dose single alkylating agent therapy and finally...
Eligibility Criteria
DISEASE CHARACTERISTICS:
Histologically proven AR and ESFT which includes: Classical, atypical and extraosseous Ewing's sarcoma, primitive peripheral neuroectodermal tumors, peripheral neuroepithelioma, primitive sarcoma of bone, and ectomesenchymoma.
Confirmed presence of tumor-specific infusion protein by documented RT-PCR which corresponds to one of the tumor specific peptides available for vaccination.
Measurable tumor.
No prior or current CNS metastases.
PRIOR/CONCURRENT THERAPY:
ARM A PATIENTS:
May be enrolled on the protocol for the first phase in the absence of RT PCR documentation of a tumor-specific fusion protein which corresponds to one of the tumor-specific peptides available for vaccination. However, RT PCR documentation at the time of tumor recurrence must occur prior to administration of immunotherapy. At time of initial tumor diagnosis, prior to any cytoreductive therapy.
ARM B PATIENTS:
Tumor recurrence occurring during or after receiving at least first line cytoreductive therapy for ESFT and AR. No more than two post-recurrence salvage regimens unless peripheral CD4+T cell number is greater than 400 cells per millimeter cubed.
At least 6 weeks since any treatments and recovered from all acute toxic effects from time in which immunotherapy will be started for this study.
No concurrent estrogen therapy during immunotherapy section of study.
PATIENT CHARACTERISTICS:
Age: 2-25 (at time of initial diagnosis of alveolar rhabdomyosarcoma).
Weight: Greater than 15 kg (at time of apheresis).
Performance status: ECOG 0-2.
Life expectancy: At least 8 weeks.
Hematopoietic:
ANC greater than 100,000/mm(3).
Hemoglobin greater than 9.0 g/dL.
Platelet count greater than 50,000/mm(3).
Hepatic:
Bilirubin less than 2.0 mg/dL (unless related to involvement by tumor).
Transaminases less than 3 times normal (unless related to involvement by tumor).
Renal:
Creatinine less than 1.5 mg/dL or creatinine clearance greater than 60 mL/min.
Cardiovascular:
No major disorder of cardiovascular system.
Cardiac ejection fraction greater than 40%.
Pulmonary:
No major disorder of pulmonary system.
OTHER:
Not pregnant or nursing.
HIV negative.
Hepatitis B or C negative.
No patients requiring daily oral corticosteroid therapy.
If allergic to eggs, egg products, or thimerosal, or have a history of Guillain-Barre syndrome, ineligible to receive influenza vaccine.
Key Trial Info
Start Date :
February 1 1996
Trial Type :
INTERVENTIONAL
End Date :
December 1 2000
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT00001498
Start Date
February 1 1996
End Date
December 1 2000
Last Update
March 4 2008
Active Locations (1)
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1
National Cancer Institute (NCI)
Bethesda, Maryland, United States, 20892