Dynamic Alterations in Blood Flow in Glaucoma Measured with Laser Speckle Contrast Imaging.
Alfred Vinnett, Jayanth Kandukuri, Christopher Le...
https://pubmed.ncbi.nlm.nih.gov/34673279Actively Recruiting
Phase Not Applicable
Age: 18Years - 88Years
All Genders
Healthy Volunteers
ID05726058
Ocular Blood Flow Imaging Study Using XyCAM for Glaucoma Assessment and Management
Led by University of Maryland, Baltimore · Updated on 2025-03-28
150
Participants Needed
1
Research Sites
213 weeks
Total Duration
On this page
Sponsors
U
University of Maryland, Baltimore
Lead Sponsor
N
National Eye Institute (NEI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to evaluate the use of the FDA-cleared retinal blood flow imaging instruments XyCAM RI and XyCAM FC in managing glaucoma. The study focuses on whether blood flow measurements can distinguish between eyes with early-stage glaucoma and matched controls, and whether the XyCAM FC can simultaneously capture stereo fundus photography and monitor ocular blood flow. Participants include healthy controls, those recommended for glaucoma assessment, and patients diagnosed with moderate to severe glaucoma. Participants will undergo multiple imaging tests including those with the XyCAM RI or XyCAM FC devices to capture retinal images and blood flow data. Standard clinical imaging such as color fundus photography, optical coherence tomography, and standard automated perimetry will also be performed. Eye drops (Tropicamide) will be used to dilate pupils before imaging sessions. After standard imaging, participants will inhale 100% oxygen through a mask and be re-imaged using the XyCAM devices to assess changes. During the study, participants will have measurements taken for blood pressure, heart rate, height, and weight. Various imaging sessions will be conducted, lasting about 80 minutes for test data and an additional 60 minutes for standard clinical data. The main outcome measured is the blood flow velocity in the retina over approximately one year. This detailed monitoring aims to provide insights into glaucoma assessment and management.
CONDITIONS
Official Title
Ocular Blood Flow Imaging for Glaucoma Assessment
Who Can Participate
Age: 18Years - 88Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age 18 and older with binocular vision
- Able to provide informed consent
- Participant is a healthy control OR recommended for glaucoma assessment OR diagnosed with moderate to severe glaucoma in at least one eye as determined by Hodapp Anderson Criteria
You will not qualify if you...
- Significant media opacity such as a visually significant cataract or corneal scar
- Previous ocular surgery except uncomplicated cataract extraction, laser trabeculoplasty (ALT or SLT), or YAG capsulotomy
- Prior ocular disease other than glaucoma
- Anatomically narrow angles or prior adverse reaction to Tropicamide or fluorescein dye
- More than 15 diopters of refractive error
- Female who is pregnant or nursing
- Diabetes mellitus
AI-Screening
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1
2
3
Trial Site Locations
Total: 1 location
1
University of Maryland Eye Associates at Redwood
Baltimore, Maryland, United States, 21201
Actively Recruiting
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Research Team
O
Osamah J Saeedi, MD, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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