Assessment of Endothelial Glycocalyx in Patients With Primary Open-angle Glaucoma: a Prospective Single-center Cross-sectional Case-control Study

What this Trial Is About

Researchers are exploring the role of the endothelial glycocalyx, a protective lining inside blood vessels, in patients with primary open-angle glaucoma, a chronic eye disease that damages the optic nerve and affects vision. The study focuses on the ischemic theory of glaucoma, which suggests that reduced blood flow to the optic nerve contributes to disease progression. The glycocalyx has been linked to vascular health in various conditions but is less studied in glaucoma. The study uses a special imaging technique called GlycoCheck to assess the microvascular system's health by measuring a MicroVascular Health score (MVHS). This score includes parameters such as capillary density, red blood cell filling percentage, and the thickness of the perfused boundary region (PBR). Participants are divided into two groups: those with primary open-angle glaucoma and those without any optic nerve pathology. Ophthalmological exams including visual acuity, eye pressure, corneal thickness, retina imaging, and visual field tests are also conducted. Participants will undergo these non-invasive assessments, including GlycoCheck and detailed eye exams, to evaluate blood vessel health and optic nerve status. Researchers will measure the thickness of the perfused boundary region as the primary outcome to better understand vascular changes in glaucoma. The study aims to provide insights into the microvascular system's role in this eye condition. Participation involves a one-time observational visit, with no treatment administered, and study-related procedures are designed to be safe and painless.

Assessment of Endothelial Glycocalyx in Patients With Primary Open-angle Glaucoma